Antimicrobial resistance (AMR) is an emerging problem in the world that has a significant
impact on our society. AMR made conventional drugs futile against microorganisms and diseases untreatable.
Plant-derived medicines are considered to be safe alternatives as compared to synthetic
drugs. Active ingredients and the mixtures of these natural medicines have been used for centuries,
due to their easy availability, low cost, and negligible side effects. Essential oils (EOs) are the secondary
metabolites that are produced by aromatic plants to protect them from microorganisms. However,
these EOs and their constituents have shown good fighting potential against drug-resistant pathogens.
These oils have been proved extremely effective antimicrobial agents in comparison to antibiotics. Also,
the combination of synthetic drugs with EOs or their components improve their efficacy. So, EOs
can be established as an alternative to synthetic antimicrobial agents to eradicate tough form of infectious
microorganisms. EO’s can interact with multiple target sites, like the destruction of cytoplasm
membrane or inhibition of protein synthesis and efflux pump, etc. The purpose of this review is to
provide information about the antimicrobial activity of EOs attained from different plants, their combination
with synthetic antimicrobials. In addition, mechanism of antimicrobial activity of several EOs
and their constituents was reported.
Keywords: Antimicrobial resistance, essential oil, mechanism, a combination with antibiotics, a combination of EOs and their
Rights & PermissionsPrintExport