Background: The synthesis of seven-membered heterocycles is a growing field
in order to explore their biological and pharmaceutical importance. 1,3,4-
Thiadiazepinesare are a notable class of heterocyclic compounds with remarkable biological
importance. 1,3,4-Thiadiazepines have been reported to have an exceptional range of
biological activities such as anti-HIV, biocidal, antimicrobial and generating agents and
used in drug design processes.
Objective: The present study highlights structural studies, chemical reactivity, synthetic
methods of monocyclic and poly-fused heterocycles and biological significance of heterocyclic
compounds incorporated 1,3,4-thiadiazepine skeleton.
Conclusion: The purpose of this assessment is to discuss the chemical assembly, reactivity and synthetic procedures
of the title compounds up till now. The reaction mechanisms are discussed, as well as, the biological
applications of the target compounds. This study will help researchers in the fields of organic and medicinal
chemistry to design and implement new procedures for the constructions of novel biological components.