A major goal in tuberculosis (TB) research is the identification, among the subjects
infected with Mycobacterium tuberculosis (Mtb), of those with active TB, or at higher risk of
developing active disease, from the latently infected subjects. The classical heterogeneity of
Mtb infection and TB disease is a major obstacle toward the identification of reliable biomarkers
that can stratify Mtb infected subjects based on disease risk. The heparin-binding
haemagglutinin (HBHA) is a mycobacterial surface antigen that is implicated in tuberculosis
(TB) pathogenesis. The host immune response against HBHA varies depending on the TB
status and several studies are supporting the role of HBHA as a useful biomarker of TB.
Keywords: tuberculosis, biomarkers, HBHA, personalized medicine.
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