Background: Phage display is an effective technology for generation and selection targeting protein for a
variety of purpose, which is based on a direct linkage between the displayed protein and the DNA sequence encoding
it and utilized in selecting peptides, improving peptides affinity and indicating protein-protein interactions. Phage
particles displaying peptide have the potential to apply in the identification of cell-specific targeting molecules, identification
of cancer cell surface biomarkers, identification anti-cancer peptide, and the design of peptide-based anticancer
Method/Results: Literature searches, reviews and assessments about Phage were performed in this review from
PubMed and Medline databases.
Conclusion: The phage display technology is an inexpensive method for expressing exogenous peptides, generating
unique peptides that bind any given target and investigating protein-protein interactions. Due to the powerful ability
to insert exogenous gene and display exogenous peptides on the surface, phages may represent a powerful peptide
delivery system that can be utilized to develop rapid, efficient, safe and inexpensive cancer therapy methods.