As multi-component reactions have been among the most important and advantageous
methodologies in organic chemistry since 150 years ago, the present review focuses
on one-pot multi-component reactions containing amines and carbon disulfide as
constant starting materials along with other essential substances to afford the corresponding
nitrogen- and sulfur-containing products in demand such as thiazolidine-2-thiones, 2-
imino-1,3-dithiolanes, 2-substituted benzothiazoles, 1,3-thiazine-2-thiones, dithiocarbamate
derivatives, and thioureas through green methodologies. This synthetic field has
been widely studied throughout the last two decades to achieve such biologically active
structures. The progress orientation of these reports towards green chemistry principles is
reviewed from 2000 to December 2017.
Keywords: Carbon disulfide, amines, multicomponent reactions, green synthesis, heteroatom containing compound, green chemistry.
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