The Unique Inhibitory IgG Receptor--FcγRIIb

Author(s): Zhenzhen Xu, Lipeng Liu, Zhe Cui, Kewei Bi, Nan Zhang, Yanfen Zhang*, Zhongcheng Liu*.

Journal Name: Protein & Peptide Letters

Volume 25 , Issue 11 , 2018

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Abstract:

Background: FcγRIIb is the only inhibitory IgG receptor, which is divided into three subtypes of FcγRIIb1, FcγRIIb2 and FcγRIIb3. It is mainly responsible for the immune balance in vivo by cross-linking with the activated receptor to intracellular transduction inhibitory signals, and it plays an important biological role in the negative regulation of innate immunity and adaptive immunity. An abnormal expression of FcγRIIb on cells would result in autoimmune diseases, infectious diseases, and so forth.

Conclusion: FcγRIIb modulates immune responses and further treats related diseases by inhibiting the activation of B lymphocytes, monocytes, mast cells, and basophils induced by activating receptors. It can be used in biotherapeutic methods such as monoclonal antibodies, chimeric recombinant proteins, bispecific antibodies, etc. Our increased understanding of FcγRIIb function also has a foundation for further research and development of FcγRIIb, which also provides potentially farreaching therapeutic implications.

Keywords: FcγRIIb, IgG receptor, BCR, Fc receptor, biological function, ITIM.

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Article Details

VOLUME: 25
ISSUE: 11
Year: 2018
Page: [966 - 972]
Pages: 7
DOI: 10.2174/0929866525666181026162216
Price: $58

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