With the unprecedented rise of drug-resistant pathogens, particularly antibiotic-resistant
bacteria, and no new antibiotics in the pipeline over the last three decades, the issue of antimicrobial
resistance has emerged as a critical public health threat. Antimicrobial Peptides (AMP) have
garnered interest as a viable solution to this grave issue and are being explored for their potential
antimicrobial applications. Given their low bioavailability in nature, tailoring new AMPs or strategizing
approaches for increasing the yield of AMPs, therefore, becomes pertinent.
The present review focuses on biotechnological interventions directed towards enhanced AMP
synthesis and revisits existing genetic engineering and synthetic biology strategies for production of
AMPs. This review further underscores the importance and potential applications of advanced gene
editing technologies for the synthesis of novel AMPs in future.
Keywords: Antimicrobial peptides, antimicrobial resistance, magnifection, genetic engineering, gene editing, CRISPR-Cas9.
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