Cyclin Dependent Kinase 9 (CDK9) as a serine/threonine kinase belongs to a great number
of CDKs. CDK9 is the main core of PTEF-b complex and phosphorylates RNA polymerase (RNAP)
II besides other transcription factors which regulate gene transcription elongation in numerous
physiological processes. Multi-functional nature of CDK9 in diverse cellular pathways proposes that it
is as an appealing target. In this review, we summarized the recent findings on the molecular
interaction of CDK9 with critical participant molecules to modulate their activity in various diseases.
Furthermore, the presented review provides a rationale supporting the use of CDK9 as a therapeutic
target in clinical developments for crucial diseases; particularly cancers will be reviewed.
Keywords: CDK9, cardiac pathway, cancer, viral agents, fibrosis, inflammation, RNAP.
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