The incidence of diabetes mellitus (DM) is on the rise, worldwide. One of the main complications
in DM is delayed wound healing and it often requires amputation. Various drugs were used to
treat DM but they presented with adverse effects. Often, patients failed to comply with such treatment.
This opened the door for complementary and alternative medicine. In the present review, we explored
the molecular concept of wound healing occurring in different stages with special emphasis to DM. We
also highlighted the potential herbal products such as NF3 (Chinese 2-Herb Formula), Zicao, Jing Wan
Hong ointment, Aleo vera, mixture of Adiantum capillus-veneris, Commiphora molmol, Aloe vera, and
henna, Phenol-rich compound sweet gel, Jinchuang ointment, San-huang-sheng-fu (S) oil, Yi Bu A Jie
extract, Astragali Radix (AR) and Rehmanniae Radix (RR), Yiqi Huayu, Tangzu yuyang ointment,
Shengji Huayu recipe, Angelica sinensis, Lithospermun erythrorhison, Hippophae rhamnoides L.,
Curcuma longa and Momordica charantia that could be used effectively to treat DM wounds. Future
clinical trials are needed for designing potential drugs which may be effective in treating DM wounds.