Chemistry of α-(arylhydrazono)-β-ketoaldehydes: Preparation and Chemical Reactivities

Author(s): Hatem M. Gaber , Sobhi M. Gomha* , Thoraya A. Farghaly* , Zeinab A. Muhammad , Mark C. Bagley .

Journal Name: Current Organic Chemistry

Volume 22 , Issue 27 , 2018

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

The following review provides up to date information about the recent progress in synthetic approaches and chemical reactivities to α-(arylhydrazono)-β-ketoaldehydes, mainly using N,N-dimethyl-β-ketoenamines as an efficient starting material. These α - (arylhydrazono)-β-ketoaldehydes have assured to be of biological interest and furnish an inlet to a new class of biologically active heterocyclic compounds for biomedical implementations. The data published until the end of 2017 have been covered.

Keywords: 2-arylhydrazonals, N, N-dimethylenamino-ketones, coupling reactions, α-(arylhydrazono)-β-ketoaldehydes, active methylene, nitrogen-nucleophiles.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 22
ISSUE: 27
Year: 2018
Page: [2599 - 2633]
Pages: 35
DOI: 10.2174/1385272822666181025145512
Price: $58

Article Metrics

PDF: 13
HTML: 1