Background: A combination therapy with PCSK9-inhibitors (PCSK9-I) and lipoprotein-apheresis
(LA) may have synergistic effects on circulating lipid and lipoprotein levels, in particular in Homozygous Familial
Hypercholesterolaemic (HoFH) subjects. The relationships between the above mentioned novel therapeutic
approaches as highly effective treatment option for Dyslipidemia in Heterozygous Familial Hypercholesterolaemic
(HeFH) patients deserve further investigation in larger datasets.
Objective: This review aims to present the role of lipoprotein apheresis in the management of familial hypercholesterolaemia
and discuss the potential advantages and disadvantages of its combination with PCSK9 inhibitors.
Methods: A comprehensive literature search regarding lipoprotein apheresis in patients with familial hypercholesterolaemia
and its combination with PCSK9 inhibitors has been performed.
Results: LA is also a potent therapeutic player having impact on inflammation and related mediators. A large
body of evidence on this is available. On the contrary, only few observations are available on PCSK9-I effects on
Conclusions: It is quite clear that further investigation on possible direct and/or indirect pleiotropic effects of
PCSK9-I on inflammatory molecules is necessary and to be expected. Evidence on both arguments with regard to
HoFH and HeFH, are reported in short.