Synthesis and Evaluation of Aromatic Surfactants as Potential Antibacterial and Cytotoxic Agents

Author(s): Kenia Barrantes, Mary Fuentes, Luz Chacón, Rosario Achí, Jorge Granados-Zuñiga, Maria José Alvarado, Luis Somarribas, José Vázquez-Tato, M. Pilar Vázquez-Tato, Julio A. Seijas, Víctor Soto Tellini*.

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 6 , 2019

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Graphical Abstract:


Two ether and one ester derivatives of the 4-nitro-3-hydroxybenzoic acid were synthesized and characterized. The in vitro antimicrobial and cytotoxic activities of the three novel compounds were also evaluated. The aromatic derivatives showed antibacterial activity against one of the four microorganisms tested and two compounds (C8 and NOBA) had a lower IC50 in HeLa cells.

Keywords: Surfactants, cytotoxic activity, antimicrobial activity, aromatic, 4-nitro-3-hidroxybenzoic acid, organic chemistry.

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Article Details

Year: 2019
Page: [478 - 484]
Pages: 7
DOI: 10.2174/1570178615666181023151308
Price: $95

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