Medicinal plants have been indispensable to human life as they are used in food,
cosmetics, medicines, nutraceuticals, perfumery, beverages and many more sectors. The medicinal
plant contains various important classes of phytochemicals and broadly they are categorized into either
primary or secondary metabolite. A large number of modern medicines are mainly derived from
plant and other natural sources. Medicinal properties of plants are mainly due to the presence of their
secondary metabolite and good examples are salicylic acid, morphine, quinine, vincristin and
vinblastine. In spite of the great discovery of allopathic medicine, plant pure phytoconstituents play
an important role in the modern medicine. Various plant based medicine are available in the market
and people are using it on the basis of the belief that it is safer compared to the allopathic medicine.
Furthermore, based on these believes, people use most of the traditional medicines in their routine
life for the treatment of numerous disorders and this is called self-medication. Quassia amara plant
belongs to Simaroubaceae family which is one of the best examples of the self-medicated plant. Traditionally
Quassia amara has antimalarial, stomachic, antianaemic, antibiotics, cytotoxic and
antiamoebic activity. Its reproductive, insecticidal, larvicidal and vermifuge properties have been also
reported in the literature. Quassinoids are the important phytoconstituents of this plant and are the
main bitter principles of Quassia amara too. Quassin is a white crystalline substance and is widely
used in Chinese herbal medicine for their bitter taste. The purpose of this review is to gain an understanding
of the Quassin and Quassia amara and to present information and knowledge regarding this
phytoconstituent. Medicinal uses, pharmacological importance and various bioanalytical methods of
Quassin and Quassia amara have been presented in this review. The benefit of this review is to get
better understanding and ideas of Quassin and Quassia amara research findings in various disciplines.
Furthermore, there is a need to perform more scientific investigation to explore the other beneficial
properties of Quassia amara and Quassin.