Background: Diabetic peripheral neuropathy (DPN) is one of the most common complications
of Type 2 diabetes mellitus (T2DM). This study was conducted to investigate the possible association
between interleukin-1β (IL-1β) rs16944 /IL-1 receptor antagonist (IL-1Ra) VNTR variants and
genetic susceptibility to DPN in a Turkish cohort.
Methods: A total of 200 subjects were enrolled in this study, 98 patients with DPN and 102 cases of
age and sex-matched healthy controls. Genotyping was performed for all individuals using PCR-RFLP
Results: IL-1β rs16944 CC genotype had a 3.20-fold increased risk for DPN (p=0.0003, OR=3.20,
95% Cl:1.72-5.96). IL-1β rs16944 CT genotype was higher in healthy control than patients (p=0.004).
IL-1β rs16944 C allele was higher in the patient group compared to controls while T allele was lower
in patients than controls (p=0.003). IL-1Ra VNTR a1/a1 and a2/a2 genotypes were lower in DPN patients
while a1/a2 genotype was higher in patients (p=0.045). The patients carrying a1/T haplotype
had decreased risk of DPN than control groups (p=0.004). The patients carrying a2/a2 genotype had
lower HDL level (p=0.039). The subjects carrying a2/a2 genotype had higher total cholesterol level
while the subjects carrying a1/a2 genotype had lower total cholesterol (p=0.026 and p=0.037, respectively).
IL-1Ra a1 allele was associated with higher HDL level (p=0.041).
Conclusion: Findings of this study indicated that the IL-1β rs16944 and IL-1Ra VNTR variants are
probably to be associated with susceptibility DPN risk in a Turkish cohort.