Background: Thiazoles and pyridines are versatile synthetic scaffolds possessing wide
spectrum of biological effects including potential antimicrobial activity.
Objective: In the efforts to develop suitable antimicrobia drugs, medicinal chemists have focused on
thiazole derivatives. A novel series of 2-thiazolyl pyridines was prepared in a one-pot three-component
reaction using 2-bromoacetyl pyridine as a starting precursor.
Method: Structure of the synthesized compounds was elucidated by spectral data (FT-IR, 1H NMR,
13C NMR, and mass) and elemental analyses. The prepared compounds were screened for their in vitro
Results: The results revealed that compounds 4a,b,e-g and 12 showed promising activity. Molecular
docking studies using MOE software were carried out for compounds 4a and 4b which exhibited potent
activities indicated by the diameter zones (4a; 3.6, 4.0, 1.2 mm) (4b; 4.2, 3.5, 1.5 mm) and the
binding affinities (4a; -5.7731, -5.3576, -4.6844 kcal mol-1) (4b; -5.9356, -2.8250, -5.3628 kcal mol-1)
against Candida albicans, Bacillus subtilis and E. coli, respectively.
Conclusion: This paper describes a facile and efficient MCR for synthesis of 2-thiazolyl pyridines
from reaction of 2-bromoacetyl pyridine with different reagents. There was an agreement between the
values of binding affinities and interactions and the data obtained from the practical antimicrobial
screening of the tested compounds.