Antispermatogenic Effect of Piper betel Leaf Stalk Extract with Reference to Kinetic Studies of 17β-hydroxy Steroid Dehydrogenase Enzyme in Testes of Albino Rats

Author(s): Govardhan Naik Amgoth, P. Venkataramanaiah, Changamma Challa*.

Journal Name: Current Enzyme Inhibition

Volume 15 , Issue 1 , 2019

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Graphical Abstract:


Abstract:

Background: In the development and maintenance of male reproductive function and fertility, steroidogenesis plays a key role.

Aims: The aim of the present study was to investigate the effect of the betel leaf stalk extract on 17β- hydroxy steroid dehydrogenase activity levels.

Methods: The observed elevation in testicular cholesterol levels may be due to decreased androgen production, which resulted in impaired spermatogenesis. The decreased steroidogenic enzyme 17β- HSD activity represents decreased androgen production by the extract administration. Reduction in enzyme active site density and Km value revealed that there was a reduction in enzyme-substrate affinities and rate of E-S complex breakdown in the administered rat testes.

Results & Conclusion: The administration of betel leaf stalk extract resulted in decreased enzyme content probably through impaired synthesis.

Keywords: 17β-HSD, Betel leaf stalk extract, cholesterol, kinetic studies, spermatogenesis, steroidogenesis.

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Article Details

VOLUME: 15
ISSUE: 1
Year: 2019
Page: [36 - 40]
Pages: 5
DOI: 10.2174/1573408014666181018113911
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