Development of New Potential Anticancer Metal Complexes Derived from 2-Hydrazinobenzothiazole

Author(s): Shadia A. Elsayed, Entsar A. Saad*, Sahar I. Mostafa.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 19 , Issue 11 , 2019

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Abstract:

Background: Due to the side effects of clinically approved anticancer drugs there is a great need to explore and develop new metal-based anticancer drug molecules of high efficiency with less or no side effects.

Objective: To synthesize new metal complexes of 2-hydrazinobenzothiazole (hbt) and to investigate their potential anticancer characteristics.

Method: New five complexes; [VO(hbt)2SO4].4H2O (1), [Ru(hbt)2Cl3(H2O)] (2), [M(hbt)2Cl2] [M(II) = Pd (3), Pt (4)] and [Ag(hbt)2].NO3 (5) were prepared and their structure was investigated by means of FTIR, 1H NMR, ESI-MS and UV-Vis spectra, elemental and thermal analysis, magnetic and molar conductance measurements. The ligand and its complexes were examined as anticancer agents against Ehrlich ascites carcinoma (EAC) and human cancer cells (hepatocellular carcinoma Hep-G2, mammary gland breast cancer MCF-7 and colorectal carcinoma HCT-116).

Results: This feature is further supported by the DNA-metal complexes binding ability. In addition, anti-oxidation activity of the complexes was investigated.

Conclusion: Complex (5) showed the highest antioxidation and anticancer activities.

Keywords: Anticancer, antioxidant, cytotoxic, DNA, palladium, silver, spectra.

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Article Details

VOLUME: 19
ISSUE: 11
Year: 2019
Page: [913 - 922]
Pages: 10
DOI: 10.2174/1389557518666181017143548
Price: $95

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