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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Review Article

Prevalence of Metallo-β-Lactamases in Acinetobacter Baumannii in Iran: A Review and Meta-Analysis

Author(s): Bashir Mohammadpour*, Samaneh Rouhi, Masoud Moradi, Rashid Ramazanzadeh, Ebrahim Saniyi, Sairan Zandi and Himen Salimizand

Volume 19, Issue 4, 2019

Page: [350 - 361] Pages: 12

DOI: 10.2174/1871526518666181016101430

Price: $65

Abstract

Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen that causes major public health concerns, especially in hospitalized patients due to acquisition of resistant genes. The aim of this study was to systematically review the published data on the prevalence and dispersion of metallo-β-lactamases (MBLs) genes in A. baumannii in different provinces of Iran and provide an overall prevalence rate using meta-analysis. All available national and international databanks from 2011 to 2017 were searched to find published studies. Quality of studies was assessed by STROBE. Due to the fact that a significant heterogeneity was observed, the random effects model was used to combine the results. Statistical analysis was performed by comprehensive meta-analysis (CMA) V2 software. Out of 78 articles, 28 were extracted based on certain inclusion and exclusion criteria. Most of the A. baumannii isolates were obtained from intensive care unit (ICU) ward of hospitals. Based on phenotypic and molecular detection tests, pooled prevalence of all MBLs was 58%, and blaVIM, blaIMP, and blaSPM-1 genes were estimated to be at 10.5, 6, and 5%, respectively. Based on the results, further attention should be given to report MBL genes in A. baumannii based on molecular detection rather than the phenotypic one. Furthermore, more effort should be focused on ICU sections in order to avoid the distribution of resistant genes.

Keywords: Metallo-β-Lactamases, Acinetobacter baumannii, Iran, meta-analysis, carbapenems, imipenem.

Graphical Abstract

[1]
Esposito, S.; De Simone, G. Update on the main MDR pathogens: prevalence and treatment options. Infez. Med., 2017, 25(4), 301-310.
[PMID: 29286008]
[2]
Giannouli, M.; Antunes, L.C.; Marchetti, V.; Triassi, M.; Visca, P.; Zarrilli, R. Virulence-related traits of epidemic Acinetobacter baumannii strains belonging to the international clonal lineages I-III and to the emerging genotypes ST25 and ST78. BMC Infect. Dis., 2013, 13, 282.
[http://dx.doi.org/10.1186/1471-2334-13-282] [PMID: 23786621]
[3]
Zarrilli, R. Acinetobacter baumannii virulence determinants involved in biofilm growth and adherence to host epithelial cells. Virulence, 2016, 7(4), 367-368.
[http://dx.doi.org/10.1080/21505594.2016.1150405] [PMID: 26856342]
[4]
Castilho, S.R.A. de, Miranda, Godoy, C.S.; Guilarde, A.O.; Cardoso, JL.; André, MCP.; Junqueira-Kipnis, AP.; Kipnis, A. Acinetobacter baumannii strains isolated from patients in intensive care units in Goiânia, Brazil: Molecular and drug susceptibility profiles. PLoS One, 2017, 12, 176-790.
[http://dx.doi.org/10.1371/journal.pone.0176790]
[5]
Bergogne-Bérézin, E.; Friedman, H. 2008.
[6]
Lemos, E.V.; de la Hoz, F.P.; Einarson, T.R.; McGhan, W.F.; Quevedo, E.; Castañeda, C.; Kawai, K. Carbapenem resistance and mortality in patients with Acinetobacter baumannii infection: systematic review and meta-analysis. Clin. Microbiol. Infect., 2014, 20(5), 416-423.
[http://dx.doi.org/10.1111/1469-0691.12363] [PMID: 24131374]
[7]
Peleg, A.Y.; Seifert, H.; Paterson, D.L. Acinetobacter baumannii: emergence of a successful pathogen. Clin. Microbiol. Rev., 2008, 21(3), 538-582.
[http://dx.doi.org/10.1128/CMR.00058-07] [PMID: 18625687]
[8]
Karageorgopoulos, D.E.; Falagas, M.E. Current control and treatment of multidrug-resistant Acinetobacter baumannii infections. Lancet Infect. Dis., 2008, 8(12), 751-762.
[http://dx.doi.org/10.1016/S1473-3099(08)70279-2] [PMID: 19022191]
[9]
Kempf, M.; Rolain, J-M. Emergence of resistance to carbapenems in Acinetobacter baumannii in Europe: clinical impact and therapeutic options. Int. J. Antimicrob. Agents, 2012, 39(2), 105-114.
[http://dx.doi.org/10.1016/j.ijantimicag.2011.10.004] [PMID: 22113193]
[10]
Bertrand, X.; Dowzicky, M.J. Antimicrobial susceptibility among gram-negative isolates collected from intensive care units in North America, Europe, the Asia-Pacific Rim, Latin America, the Middle East, and Africa between 2004 and 2009 as part of the Tigecycline Evaluation and Surveillance Trial. Clin. Ther., 2012, 34(1), 124-137.
[http://dx.doi.org/10.1016/j.clinthera.2011.11.023] [PMID: 22154196]
[11]
Pourhajibagher, M.; Hashemi, F.B.; Pourakbari, B.; Aziemzadeh, M.; Bahador, A. Antimicrobial resistance of Acinetobacter baumannii to imipenem in Iran: a systematic review and meta-analysis. Open Microbiol. J., 2016, 10, 32-42.
[http://dx.doi.org/10.2174/1874285801610010032] [PMID: 27099638]
[12]
Tsakris, A.; Poulou, A.; Kristo, I.; Pittaras, T.; Spanakis, N.; Pournaras, S.; Markou, F. Large dissemination of VIM-2-metallo-β-lactamase-producing pseudomonas aeruginosa strains causing health care-associated community-onset infections. J. Clin. Microbiol., 2009, 47(11), 3524-3529.
[http://dx.doi.org/10.1128/JCM.01099-09] [PMID: 19776233]
[13]
Bush, K.; Jacoby, G.A.; Medeiros, A.A. A functional classification scheme for beta-lactamases and its correlation with molecular structure. Antimicrob. Agents Chemother., 1995, 39(6), 1211-1233.
[http://dx.doi.org/10.1128/AAC.39.6.1211] [PMID: 7574506]
[14]
Magalhães, V.; Lins, A.K.; Magalhães, M. Metallo-beta-lactamase producing Pseudomonas aeruginosa strains isolated in hospitals in Recife, PE, Brazil. Braz. J. Microbiol., 2005, 36, 123-125.
[http://dx.doi.org/10.1590/S1517-83822005000200005]
[15]
Yan, J.J.; Hsueh, P.R.; Ko, W.C.; Luh, K.T.; Tsai, S.H.; Wu, H.M.; Wu, J.J. Metallo-β-lactamases in clinical Pseudomonas isolates in Taiwan and identification of VIM-3, a novel variant of the VIM-2 enzyme. Antimicrob. Agents Chemother., 2001, 45(8), 2224-2228.
[http://dx.doi.org/10.1128/AAC.45.8.2224-2228.2001] [PMID: 11451678]
[16]
Gales, A.C.; Menezes, L.C.; Silbert, S.; Sader, H.S. Dissemination in distinct Brazilian regions of an epidemic carbapenem-resistant Pseudomonas aeruginosa producing SPM metallo-β-lactamase. J. Antimicrob. Chemother., 2003, 52(4), 699-702.
[http://dx.doi.org/10.1093/jac/dkg416] [PMID: 12951331]
[17]
Franco, M.R.G.; Caiaffa-Filho, H.H.; Burattini, M.N.; Rossi, F. Metallo-beta-lactamases among imipenem-resistant Pseudomonas aeruginosa in a Brazilian university hospital. Clinics (São Paulo), 2010, 65(9), 825-829.
[http://dx.doi.org/10.1590/S1807-59322010000900002] [PMID: 21049207]
[18]
Lagatolla, C.; Edalucci, E.; Dolzani, L.; Riccio, M.L.; De Luca, F.; Medessi, E.; Rossolini, G.M.; Tonin, E.A. Molecular evolution of metallo-β-lactamase-producing Pseudomonas aeruginosa in a nosocomial setting of high-level endemicity. J. Clin. Microbiol., 2006, 44(7), 2348-2353.
[http://dx.doi.org/10.1128/JCM.00258-06] [PMID: 16825348]
[19]
Cornaglia, G.; Mazzariol, A.; Lauretti, L.; Rossolini, G.M.; Fontana, R. Hospital outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-1, a novel transferable metallo-β-lactamase. Clin. Infect. Dis., 2000, 31(5), 1119-1125.
[http://dx.doi.org/10.1086/317448] [PMID: 11073738]
[20]
Peña, C.; Suarez, C.; Tubau, F.; Gutierrez, O.; Domínguez, A.; Oliver, A.; Pujol, M.; Gudiol, F.; Ariza, J. Nosocomial spread of Pseudomonas aeruginosa producing the metallo-β-lactamase VIM-2 in a Spanish hospital: clinical and epidemiological implications. Clin. Microbiol. Infect., 2007, 13(10), 1026-1029.
[http://dx.doi.org/10.1111/j.1469-0691.2007.01784.x] [PMID: 17651449]
[21]
Tsakris, A.; Pournaras, S.; Woodford, N.; Palepou, M-F.I.; Babini, G.S.; Douboyas, J.; Livermore, D.M. Outbreak of infections caused by Pseudomonas aeruginosa producing VIM-1 carbapenemase in Greece. J. Clin. Microbiol., 2000, 38(3), 1290-1292.
[PMID: 10699045]
[22]
Gholamine, B.; Mohajeri, P.; Fathi, M.; Rezaei, M.; Zahrabi, A. Prevalence of acinetobacter clinical isolates producing extended spectrum beta-lactamase (ESBL) and metallo-beta-lactamase (MBL) in Kermanshah academic hospitals. Res. Pharm. Sci., 2012, 7, 904.
[23]
Sarhaddi, N.; Dolatabadi, S. Amel. Jamehdar, S. Drug resistance pattern of carbapenem-resistant Acinetobacter baumannii isolated from a referral burn center in northeast of Iran. MUMS, 2016, 59, 1-8.
[24]
Goudarzi, H.; Hashemi, A.; Fatemeh, F.; Noori, M.; Erfanimanesh, S.; Yosefi, N.; Heidary, M.; Khoshnood, S.; Houri, H.R. Detection of blaDIM, blaAIM, blaGIM, blaNDM and blaVIM Genes among Acinetobacter baumannii strains isolated from hospitalized patients in Tehran hospitals, Iran. Iran. J. Microbiol., 2016, 9, 32-39.
[25]
Vazirzadeh, J.; Heidari, L.; Ghajavand, H. Frequency of Metallo-β-Lactamase and Antimicrobial Resistance Patterns of Acinetobacter Baumannii in Carbapenem-Resistant Isolates from Intensive Care Units of the Hospitals in Isfahan City, Iran. JIMS, 2015, 32, 2094-2103.
[26]
Abedin, M.S.F. Acinetobacter and Methalo -β - Lactamase Genes. IJIDTM, 2012, 17, 29-33.
[27]
Peymani, A.; Nahaei, M.R.; Farajnia, S.; Hasani, A.; Mirsalehian, A.; Sohrabi, N.; Abbasi, L. High prevalence of metallo-beta-lactamase-producing acinetobacter baumannii in a teaching hospital in Tabriz, Iran. Jpn. J. Infect. Dis., 2011, 64(1), 69-71.
[PMID: 21266761]
[28]
Fallah, F.; Noori, M.; Hashemi, A.; Goudarzi, H.; Karimi, A.; Erfanimanesh, S.; Alimehr, S. Prevalence of bla NDM, bla PER, bla VEB, bla IMP, and bla VIM Genes among Acinetobacter baumannii Isolated from Two Hospitals of Tehran, Iran. Scientifica (Cairo), 2014.2014245162
[http://dx.doi.org/10.1155/2014/245162] [PMID: 25133013]
[29]
Shahcheraghi, F.; Abbasalipour, M.; Feizabadi, M.; Ebrahimipour, G.; Akbari, N. Isolation and genetic characterization of metallo-β-lactamase and carbapenamase producing strains of Acinetobacter baumannii from patients at Tehran hospitals. Iran. J. Microbiol., 2011, 3(2), 68-74.
[PMID: 22347585]
[30]
Hakemi Vala, M.; Hallajzadeh, M.; Hashemi, A.; Goudarzi, H.; Tarhani, M.; Sattarzadeh Tabrizi, M.; Bazmi, F. Detection of Ambler class A, B and D ß-lactamases among Pseudomonas aeruginosa and Acinetobacter baumannii clinical isolates from burn patients. Ann. Burns Fire Disasters, 2014, 27(1), 8-13.
[PMID: 25249841]
[31]
Azimi, L.; Talebi, M.; Pourshafie, M.R.; Owlia, P.; Rastegar Lari, A. Characterization of carbapenemases in extensively drug resistance Acinetobacter baumannii in a burn care center in Iran. Int. J. Mol. Cell. Med., 2015, 4(1), 46-53.
[PMID: 25815282]
[32]
Noori, N.; Vandyosefi, J.; Sabet, F.; Ashrafi, S.; Ghazvini, K. Frequency of IMP-1 and VIM Genes among Metallo-beta-Lactamase Producing Acinetobacter spp. Isolated from Health Care Associated Infections inNortheast of Iran. J. Med. Bacteriol., 2015, 2, 11-16.
[33]
Mahdian, S.; Sadeghifard, N.; Pakzad, I.; Ghanbari, F.; Soroush, S.; Azimi, L.; Rastegar-Lari, A.; Giannouli, M.; Taherikalani, M. Acinetobacter baumannii clonal lineages I and II harboring different carbapenem-hydrolyzing-β-lactamase genes are widespread among hospitalized burn patients in Tehran. J. Infect. Public Health, 2015, 8(6), 533-542.
[http://dx.doi.org/10.1016/j.jiph.2015.04.030] [PMID: 26111484]
[34]
Davoodi, S.; Boroumand, M.A.; Sepehriseresht, S.; Pourgholi, L. Detection of VIM-and IMP-type metallo-beta-lactamase genes in Acinetobacter baumannii Isolates from patients in two hospitals in Tehran. Iranian J. Biotechnol., 2015, 13(1), 63-67.
[http://dx.doi.org/10.15171/ijb.1088] [PMID: 28959283]
[35]
Mohammadzadeh, M.; Tavakoli, M.; Mohebi, A.; Aghayi, S. Phenotypic and genotypic detection of metallo-beta-lactamases among imipenem resistant gram negative isolates. J. Med. Bacteriol., 2016, 5, 36-42.
[36]
Moghadam, M.N.; Motamedifar, M.; Sarvari, J.; Sedigh, E.S.; Mousavi, S.M.; Moghadam, F.N. Emergence of multidrug resistance and metallo-beta-lactamase producing acinetobacter baumannii isolated from patients in Shiraz, Iran. Ann. Med. Health Sci. Res., 2016, 6(3), 162-167.
[http://dx.doi.org/10.4103/2141-9248.183946] [PMID: 27398247]
[37]
Sobouti, B.; Khosravi, N.; Daneshvar, A.; Fallah, S.; Moradi, M.; Ghavami, Y. Prevalence of beta lactamase producing species of pseudomonas and acinetobacter in pediatric burn patients. Ann. Burns Fire Disasters, 2015, 28(3), 171-177.
[PMID: 27279802]
[38]
Shoja, S.; Moosavian, M.; Peymani, A.; Tabatabaiefar, M.A.; Rostami, S.; Ebrahimi, N. Genotyping of carbapenem resistant Acinetobacter baumannii isolated from tracheal tube discharge of hospitalized patients in intensive care units, Ahvaz, Iran. Iran. J. Microbiol., 2013, 5(4), 315-322.
[PMID: 25848498]
[39]
Farsiani, H.; Mosavat, A.; Soleimanpour, S.; Nasab, M.N.; Salimizand, H.; Jamehdar, S.A.; Ghazvini, K.; Aryan, E.; Baghani, A.A. Limited genetic diversity and extensive antimicrobial resistance in clinical isolates of Acinetobacter baumannii in north-east Iran. J. Med. Microbiol., 2015, 64(7), 767-773.
[http://dx.doi.org/10.1099/jmm.0.000090] [PMID: 25991693]
[40]
Maspi, H.; Mahmoodzadeh Hosseini, H.; Amin, M.; Imani Fooladi, A.A. High prevalence of extensively drug-resistant and metallo beta-lactamase-producing clinical Acinetobacter baumannii in Iran. Microb. Pathog., 2016, 98, 155-159.
[http://dx.doi.org/10.1016/j.micpath.2016.07.011] [PMID: 27448835]
[41]
Azimi, L.; Talebi, M.; Khodaei, F.; Najafi, M.; Lari, A.R. Comparison of multiple-locus variable-number tandem-repeat analysis with pulsed-field gel electrophoresis typing of carbapenemases producing Acinetobacter baumannii isolated from burn patients. Burns, 2016, 42(2), 441-445.
[http://dx.doi.org/10.1016/j.burns.2015.08.024] [PMID: 26774604]
[42]
Dadgar, J.; Pakdel, M.N.; Rasooli, I.; Yadegarinia, D.; Firouz-Amani, M.A.; Kazemi, S. DadgarPakde, F.; Aghabozorgi, S. Prediction of Antibiotic Influence by Presence of Some β-lactamase Gene in Acinetobacter Infected Patients Hospitalized in Tehran, Iran. JAEBS, 2012, 2, 60-65.
[43]
Nazari-Monazam, A.; Hosseini-Doust, S.R.; Mirnejad, R. Prevalence PER and VEB beta-lactamase genes among Acinetobacter baumannii isolated from patients in Tehran by PCR. Iran. J. Microbiol., 2015, 8, 28-35.
[44]
Noori, M.; Karimi, A.; Fallah, F.; Hashemi, A.; Alimehr, S.; Goudarzi, H.; Aghamohammad, S.H. High prevalence of metallo-beta-lactamase producing Acinetobacter baumannii isolated from two hospitals of Tehran, Iran. Arch. Pediatr. Infect. Dis, 2014, 2, 1-5.
[http://dx.doi.org/10.5812/pedinfect.15439]
[45]
Alan, T.F.; Goudarzi, H.; Fallah, F.; Hashemi, A.; Doustdar, F.; Bostan, H. Detection of blaNDM, blaDIM, blaIMP, blaVIM and blaCTX-M-15 beta-lactamase genes among Pseudomonas aeruginosa and Acinetobacter baumannii strains isolated from two hospitals of Tehran, Iran. NBM, 2016, 4, 153-158.
[46]
Goudarzi, H.; Mirsamadi, E.S.; Ghalavand, Z.; Vala, M.H.; Mirjalali, H.; Hashemi, A.; Ghasemi, E. Molecular detection of metallo-beta-lactamase genes in clinical isolates of Acinetobacter baumannii. J. Pure Appl. Microbiol., 2015, 9, 145-151.
[47]
Safari, M.; Mozaffari Nejad, A.S.; Bahador, A.; Jafari, R.; Alikhani, M.Y. Prevalence of ESBL and MBL encoding genes in Acinetobacter baumannii strains isolated from patients of intensive care units (ICU). Saudi J. Biol. Sci., 2015, 22(4), 424-429.
[http://dx.doi.org/10.1016/j.sjbs.2015.01.004] [PMID: 26150748]
[48]
Tarashi, S.; Goudarzi, H.; Erfanimanesh, S.; Pormohammad, A.; Hashemi, A. Phenotypic and molecular detection of metallo-beta-lactamase genes among imipenem resistant Pseudomonas aeruginosa and Acinetobacter baumannii strains isolated from patients with burn injuries; Arch Pediatr Infect Dis, 2016, p. 11.
[49]
Bagheri-Josheghani, S.; Moniri, R.; Firoozeh, F.; Sehhat, M.; Ghenaat-Ghamsari, E. Emergence of multidrug resistant, extended-spectrum β-lactamase and metallo-β-lactamase strain of Acinetobacter baumannii in ICU ward of Kashan Beheshti Hospital during 2013-14. Feyz, 2016, 20, 49-56.
[50]
Salimizand, H.; Modarresi, F.; Azizi, O.; Mansouri, S.; Rahmati, M.; Barkhordari, K. Antimicrobial profile and phenotypic metallo-β-lactamase detection of Acinetobacter baumannii isolated from clinical and environmental specimens. ZJRMS, 2015, 17, 51-55.
[http://dx.doi.org/10.17795/zjrms993]
[51]
Tang, S.S.; Apisarnthanarak, A.; Hsu, L.Y. Mechanisms of β-lactam antimicrobial resistance and epidemiology of major community- and healthcare-associated multidrug-resistant bacteria. Adv. Drug Deliv. Rev., 2014, 78, 3-13.
[http://dx.doi.org/10.1016/j.addr.2014.08.003] [PMID: 25134490]
[52]
Soltani, B.; Heidari, H.; Ebrahim-Saraie, H.S.; Hadi, N.; Mardaneh, J.; Motamedifar, M. Molecular characteristics of multiple and extensive drug-resistant Acinetobacter baumannii isolates obtained from hospitalized patients in Southwestern Iran. Infez. Med., 2018, 26(1), 67-76.
[PMID: 29525800]
[53]
Rezaei, A.; Fazeli, H.; Moghadampour, M.; Halaji, M.; Faghri, J. Determination of antibiotic resistance pattern and prevalence of OXA-type carbapenemases among Acinetobacter baumannii clinical isolates from inpatients in Isfahan, central Iran. Infez. Med., 2018, 26(1), 61-66.
[PMID: 29525799]
[54]
Mano, Y.; Saga, T.; Ishii, Y.; Yoshizumi, A.; Bonomo, R.A.; Yamaguchi, K.; Tateda, K. Molecular analysis of the integrons of metallo-β-lactamase-producing Pseudomonas aeruginosa isolates collected by nationwide surveillance programs across Japan. BMC Microbiol., 2015, 15, 41-48.
[http://dx.doi.org/10.1186/s12866-015-0378-8] [PMID: 25881168]
[55]
Amudhan, M.S.; Sekar, U.; Kamalanathan, A.; Balaraman, S. bla(IMP) and bla(VIM) mediated carbapenem resistance in Pseudomonas and Acinetobacter species in India. J. Infect. Dev. Ctries., 2012, 6(11), 757-762.
[http://dx.doi.org/10.3855/jidc.2268] [PMID: 23277500]
[56]
Pitout, J.D.; Gregson, D.B.; Poirel, L.; McClure, J.A.; Le, P.; Church, D.L. Detection of Pseudomonas aeruginosa producing metallo-β-lactamases in a large centralized laboratory. J. Clin. Microbiol., 2005, 43(7), 3129-3135.
[http://dx.doi.org/10.1128/JCM.43.7.3129-3135.2005] [PMID: 16000424]
[57]
Poirel, L.; Nordmann, P. Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin. Microbiol. Infect., 2006, 12(9), 826-836.
[http://dx.doi.org/10.1111/j.1469-0691.2006.01456.x] [PMID: 16882287]
[58]
Ndugulile, F.; Jureen, R.; Harthug, S.; Urassa, W.; Langeland, N. Extended spectrum β-lactamases among Gram-negative bacteria of nosocomial origin from an intensive care unit of a tertiary health facility in Tanzania. BMC Infect. Dis., 2005, 5, 86.
[http://dx.doi.org/10.1186/1471-2334-5-86] [PMID: 16225701]
[59]
Moyo, S.J.; Aboud, S.; Kasubi, M.; Lyamuya, E.F.; Maselle, S.Y. Antimicrobial resistance among producers and non-producers of extended spectrum beta-lactamases in urinary isolates at a tertiary Hospital in Tanzania. BMC Res. Notes, 2010, 3, 348.
[http://dx.doi.org/10.1186/1756-0500-3-348] [PMID: 21184671]
[60]
Manyahi, J.; Matee, M.I.; Majigo, M.; Moyo, S.; Mshana, S.E.; Lyamuya, E.F. Predominance of multi-drug resistant bacterial pathogens causing surgical site infections in Muhimbili National Hospital, Tanzania. BMC Res. Notes, 2014, 7(500), 500.
[http://dx.doi.org/10.1186/1756-0500-7-500] [PMID: 25100042]
[61]
Mshana, S.E.; Imirzalioglu, C.; Hain, T.; Domann, E.; Lyamuya, E.F.; Chakraborty, T. Multiple ST clonal complexes, with a predominance of ST131, of Escherichia coli harbouring blaCTX-M-15 in a tertiary hospital in Tanzania. Clin. Microbiol. Infect., 2011, 17(8), 1279-1282.
[http://dx.doi.org/10.1111/j.1469-0691.2011.03518.x] [PMID: 21595794]
[62]
Bonnin, R.A.; Naas, T.; Poirel, L.; Nordmann, P. Phenotypic, biochemical, and molecular techniques for detection of metallo-β-lactamase NDM in Acinetobacter baumannii. J. Clin. Microbiol., 2012, 50(4), 1419-1421.
[http://dx.doi.org/10.1128/JCM.06276-11] [PMID: 22259204]
[63]
Flokas, M.E.; Karanika, S.; Alevizakos, M.; Mylonakis, E. Prevalence of ESBL-Producing Enterobacteriaceae in Pediatric Bloodstream Infections: A Systematic Review and Meta-Analysis. PLoS One, 2017, 12(1)e0171216
[http://dx.doi.org/10.1371/journal.pone.0171216] [PMID: 28141845]
[64]
Walsh, T.R.; Toleman, M.A.; Poirel, L.; Nordmann, P. Metallo-beta-lactamases: the quiet before the storm? Clin. Microbiol. Rev., 2005, 18(2), 306-325.
[http://dx.doi.org/10.1128/CMR.18.2.306-325.2005] [PMID: 15831827]
[65]
Marshall, B.M.; Levy, S.B. Food animals and antimicrobials: impacts on human health. Clin. Microbiol. Rev., 2011, 24(4), 718-733.
[http://dx.doi.org/10.1128/CMR.00002-11] [PMID: 21976606]
[66]
Aksoy, M.D.; Çavuşlu, Ş.; Tuğrul, H.M. Investigation of metallo beta lactamases and oxacilinases in carbapenem resistant Acinetobacter baumannii strains isolated from inpatients. Balkan Med. J., 2015, 32(1), 79-83.
[http://dx.doi.org/10.5152/balkanmedj.2015.15302] [PMID: 25759776]
[67]
Swe Swe-Han, K.; Mlisana, K.P.; Pillay, M. Analysis of clinical and microbiological data on Acinetobacter baumannii strains assist the preauthorization of antibiotics at the patient level for an effective antibiotic stewardship program. J. Infect. Public Health, 2017, 10(5), 608-616.
[http://dx.doi.org/10.1016/j.jiph.2017.01.014] [PMID: 28237694]
[68]
Raka, L.; Kalenć, S.; Bosnjak, Z.; Budimir, A.; Katić, S.; Sijak, D.; Mulliqi-Osmani, G.; Zoutman, D.; Jaka, A. Molecular epidemiology of Acinetobacter baumannii in central intensive care unit in Kosova Teaching Hospital. Braz. J. Infect. Dis., 2009, 13(6), 408-413.
[http://dx.doi.org/10.1590/S1413-86702009000600004] [PMID: 20464330]
[69]
Sileem, A.E.; Said, A.M.; Meleha, M.S. Acinetobacter baumannii in ICU patients: A prospective study highlighting their incidence, antibiotic sensitivity pattern and impact on ICU stay and mortality. Egypt. J. Chest Dis. Tuberc., 2017, 66, 693-698.
[http://dx.doi.org/10.1016/j.ejcdt.2017.01.003]
[70]
Nordmann, P.; Dortet, L.; Poirel, L. Chapter 21 - Infections Due to NDM-1 Producers. Emerg. Infect. Dis., 2014, 273-293.

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