1,3,4-Oxadiazole, a five-membered aromatic ring can be seen in a number of synthetic molecules.
The peculiar structural feature of 1,3,4-oxadiazole ring with pyridine type of nitrogen atom is
beneficial for 1,3,4-oxadiazole derivatives to have effective binding with different enzymes and receptors
in biological systems through numerous weak interactions, thereby eliciting an array of bioactivities.
Research in the area of development of 1,3,4-oxadiazole-based derivatives has become an interesting
topic for the scientists. A number of 1,3,4-oxadiazole based compounds with high therapeutic potency
are being extensively used for the treatment of different ailments, contributing to enormous development
value. This work provides a systematic and comprehensive review highlighting current developments
of 1,3,4-oxadiazole based compounds in the entire range of medicinal chemistry such as
anticancer, antifungal, antibacterial, antitubercular, anti-inflammatory, antineuropathic, antihypertensive,
antihistaminic, antiparasitic, antiobesity, antiviral, and other medicinal agents. It is believed that
this review will be of great help for new thoughts in the pursuit for rational designs for the development
of more active and less toxic 1,3,4-oxadiazole based medicinal agents.