Tuberculosis (TB) takes the second place among the reasons for mortality from infectious
diseases. For this reason, the problem of tuberculosis treatment requires urgent attention all over the
world. Some 2-amino substituted 1,3-benzothiazin-4-ones (2-amino-1,3-BTZs) represent a promising
new class of antitubercular agents. Other 1,3-benzothiazin-4-one derivatives, mostly 2-aryl and 2-
(pyridin-2-yl) ones, are attractive due to their ability to suppress oxidative stress-induced cardiomyocyte
apoptosis. This review covers the synthetic approaches to 2-amino- and 2-aryl(heteryl) substituted
1,3-benzothiazin-4-ones (1,3-BTZs). A brief overview of structure-activity relationships is presented.
Keywords: Antitubercular agent, 1, 3-Benzothiazin-4-one, Cyclocondensation, 2-Mercaptobenzoic acid, 2-Halogenobenzoyl isothiocyanate.
Rights & PermissionsPrintExport