Potential of Nanoparticles in Combating Candida Infections

Author(s): Faizan Abul Qais , Mohd Sajjad Ahmad Khan , Iqbal Ahmad* , Abdullah Safar Althubiani .

Journal Name: Letters in Drug Design & Discovery

Volume 16 , Issue 5 , 2019

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Graphical Abstract:


Abstract:

Aims: The aim of this review is to survey the recent progress made in developing the nanoparticles as antifungal agents especially the nano-based formulations being exploited for the management of Candida infections.

Discussion: In the last few decades, there has been many-fold increase in fungal infections including candidiasis due to the increased number of immunocompromised patients worldwide. The efficacy of available antifungal drugs is limited due to its associated toxicity and drug resistance in clinical strains. The recent advancements in nanobiotechnology have opened a new hope for the development of novel formulations with enhanced therapeutic efficacy, improved drug delivery and low toxicity.

Conclusion: Metal nanoparticles have shown to possess promising in vitro antifungal activities and could be effectively used for enhanced and targeted delivery of conventionally used drugs. The synergistic interaction between nanoparticles and various antifungal agents have also been reported with enhanced antifungal activity.

Keywords: Antifungal, Candida albicans, candidiasis, nanoparticles, synergy, nanobiotechnology.

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VOLUME: 16
ISSUE: 5
Year: 2019
Page: [478 - 491]
Pages: 14
DOI: 10.2174/1570180815666181015145224
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