Design, Synthesis, Antimicrobial Evaluation and Molecular Modeling Study of New 2-mercaptoimidazoles (Series-III)

(E-pub Ahead of Print)

Author(s): Nidhi Rani , Randhir Singh*.

Journal Name: Letters in Drug Design & Discovery

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Abstract:

A series of novel substituted 2-mercaptoimidazoles was synthesised efficiently and in high yields using one-pot synthesis from m-hydroxyacetophenones. The structures of the newly synthesized compounds were established, their molecular activity was investigated against some bacteria and fungi were further validated using molecular docking study. The compounds exhibited excellent antimicrobial potency against the tested micro-organism.

Keywords: Mercaptoimidazoles, imidazoles, molecular modeling, antifungal, antibacterial.

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1570180815666181015144431
Price: $95