Background: Malaria remains a common life-threatening infectious disease across the
globe due to the development of resistance by Plasmodium parasite against most antimalarial
drugs. The situation demands new and effective drug candidates against Plasmodium.
Objectives: The objective of this study is to design, synthesize and test novel quinoline based
molecules against the malaria parasite.
Method: C-2 and C-8 modified quinoline analogs obtained via C-H bond functionalization approach
were synthesized and evaluated for inhibition of growth of P. falciparum grown in human
red blood cells using SYBR Green microtiter plate based screening. Computational molecular
docking studies were carried out with top fourteen molecules using Autodoc software.
Result: The biological evaluation results revealed good activity of quinoline-8-acrylate 3f (IC50
Keywords: Quinolines, antiplasmodial activity, Plasmodium falciparum, resistance index, docking study.
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