Background: Exogenous antioxidants are considered as a promising therapeutic approach
to treat neurodegenerative diseases since they could prevent and/or minimize the neuronal
damage by oxidation.
Objective: Three series of lipophilic compounds structurally based on scutellarein (2), which is one
metabolite of scutellarin (1) in vivo, have been designed and synthesized.
Method: Their antioxidant activity was evaluated by detecting the 2-thiobarbituric acid reactive
substance (TBARS) produced in the ferrous salt/ascorbate-induced autoxidation of lipids, which
were present in microsomal membranes of rat hepatocytes. The lipophilicity of these compounds
indicated as partition coefficient between n-octanol and buffer was investigated by ultraviolet
Results: This study indicated that compound 5e which had a benzyl group substituted at the C4'-
OH position showed a potent antioxidant activity and good lipophilicity.
Conclusion: 5e could be an effective candidate for preventing or reducing the oxidative status associated
with the neurodegenerative processes.
Keywords: scutellarin, scutellarein, antioxidant, lipophilicity, neurodegenerative
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