Gastrointestinal Protective Effect of Zizyphus xylopyrus (Retz) Wild Leaf Extract Against Indomethacin and HCl-EtOH Induced Ulcers

(E-pub Ahead of Print)

Author(s): Shweta Jain, Sourabh Jain, Nagendra S Chauhan, Ankur Vaidya*.

Journal Name: Current Traditional Medicine

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Background: Zizyphus xylopyrus (Retz.) Willd. (Rhamnaceae) is a straggling shrub or a small tree, armed with spines, found throughout north-­‐western India, Pakistan and China. Method: The aerial and root barks, leaves and fruits of Zizyphus species are used in medicine for the treatment of various diseases such as weakness, liver complaints, obesity, diabetes, skin infections, fever, diarrhea, insomnia and digestive disorders. Ethanolic extract of leaves of Zizyphus xylopyrus (Retz) Wild was prepared by solvent extraction and subjected to study the protective effect against Indomethacin and HCl-EtOH induced ulcer using Ranitidine (100 mg/kg) and Omeprazole (8mg/kg) as standard respectively. Results: Histopathological lesions with marked disorientation of the gastric epithelium were observed in negative control, while extract treated rats showed a better protected mucosa with intact epithelium in comparison to standard treated rats. Ulcer index and percentage ulcer protection also represent protecting effects of the extract. Conclusion: Ethanolic extract of Z. xylopyrus (Retz) Wild leaves extract was found to be significantly protective against gastric ulcers.

Keywords: Gastric ulcer; Indomethacin; HCl-EtOH; Zizyphus xylopyrus (Retz)

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/2215083804666181012124047
Price: $95