Background: Cystic Fibrosis (CF), one of the most frequent genetic diseases, is characterized
by the production of viscous mucus in several organs. In the lungs, mucus clogs the airways and
traps bacteria, leading to recurrent/resistant infections and lung damage. For cystic fibrosis patients,
respiratory failure is still lethal in early adulthood since available treatments display incomplete efficacy.
Objective: The objective of this review is to extend the current knowledge in the field of available
treatments for cystic fibrosis. A special focus has been given to inhaled peptide-based drugs.
Methods: The current review is based on recent and/or relevant literature and patents already available
in various scientific databases, which include PubMed, PubMed Central, Patentscope and Science Direct.
The information obtained through these diverse databases is compiled, critically interpreted and
presented in the current study. An in-depth but not systematic approach to the specific research question
has been adopted.
Results: Recently, peptides have been proposed as possible pharmacologic agents for the treatment of
respiratory diseases. Of note, peptides are suitable to be administered by inhalation to maximize efficacy
and reduce systemic side effects. Moreover, innovative delivery carriers have been developed for
drug administration through inhalation, allowing not only protection against proteolysis, but also a prolonged
and controlled release.
Conclusion: Here, we summarize newly patented peptides that have been developed in the last few
years and advanced technologies for inhaled drug delivery to treat cystic fibrosis.