Titanium Tetrachloride-mediated Synthesis of Diarylmethanes through the Reaction of Benzyl Alcohol Derivatives with Aromatic Substrates

Author(s): Antonella Leggio*, Emilia Lucia Belsito, Alessandra Comandè, Valentina Papaianni, Angelo Liguori*.

Journal Name: Current Organic Chemistry

Volume 22 , Issue 21 , 2018

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Titanium tetrachloride has been successfully used in the benzylation of aromatic substrates with a series of benzyl alcohols under mild reaction conditions. With monosubstituted aromatic substrates, ortho and para-substituted products are obtained in almost comparable amounts. With sterically hindered benzyl alcohol derivatives almost exclusively para-substitution occurs.

Keywords: Benzyl alcohol, diarylmethanes, friedel crafts reactions, substituted benzyl alcohols, titanium tetrachloride, aromatic substrates.

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 22
ISSUE: 21
Year: 2018
Page: [2117 - 2123]
Pages: 7
DOI: 10.2174/1385272822666181010125902
Price: $58

Article Metrics

PDF: 11
HTML: 1