Structural and Molecular Tear Film Changes in Glaucoma

Author(s): Rodolfo Mastropasqua*, Luca Agnifili, Leonardo Mastropasqua.

Journal Name: Current Medicinal Chemistry

Volume 26 , Issue 22 , 2019

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Abstract:

The Tear Film (TF) is a trilaminar and dynamic fluid covering the entire Ocular Surface (OS), consisting of a mucus, aqueous, and lipid layer deeply interacting between them. Because of its structure and functions, TF plays a pivotal role in the preservation of the OS integrity and the quality of vision. Medical therapy for glaucoma is recognized to profoundly disturb the OS homeostasis by altering all components of the ocular surface unit, including TF. The presence of preservatives, the number of daily eye drops instillations, and the duration of therapy are the main contributors to TF changes. From the physio-pathological side, TF alterations are induced by toxic and allergic mechanisms and result from goblet cell and Meibomian gland loss, dysfunction of accessory lacrimal glands, and epithelial disruption.

In detail, TF changes are represented by mucus layer thinning, reduced mucin concentration, aqueous layer volume reduction, and lipid layer thinning with increased tear evaporation. Hyper- osmolarity and instability represent the main hallmarks of these changes and are an expression of a iatrogenic form of dry eye. TF undergoes also molecular modifications that primarily reflect a therapy- or disease-induced inflammatory status of the OS. Over the last years, this field of research aimed a progressively growing interest since molecular variations may be considered as potential candidate biomarkers of glaucoma. The aim of this review is to report the main TF changes occurring during glaucoma, exploring the relationship they may have with the glaucoma-related ocular surface disease and the patient quality of life, and their utility as potential biomarkers of disease.

Keywords: Tear film, glaucoma, anti-glaucoma drugs, glaucoma filtration surgery, ocular surface disease, quality of life, glaucoma biomarkers.

[1]
Agnifili, L.; Pieragostino, D.; Mastropasqua, A.; Fasanella, V.; Brescia, L.; Tosi, G.M.; Sacchetta, P.; Mastropasqua, L. Molecular biomarkers in primary open-angle glaucoma: From noninvasive to invasive. Prog. Brain Res, 2015, 221, 1-32.
[http://dx.doi.org/10.1016/bs.pbr.2015.05.006] [PMID: 26518070]
[2]
Zhou, L.; Beuerman, R.W. Tear analysis in ocular surface diseases. Prog. Retin. Eye Res., 2012, 31(6), 527-550.
[http://dx.doi.org/10.1016/j.preteyeres.2012.06.002] [PMID: 22732126]
[3]
Tham, Y.C.; Li, X.; Wong, T.Y.; Quigley, H.A.; Aung, T.; Cheng, C.Y. Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis. Ophthalmology, 2014, 121(11), 2081-2090.
[http://dx.doi.org/10.1016/j.ophtha.2014.05.013] [PMID: 24974815]
[4]
von Thun Und Hohenstein-Blaul, N.; Funke, S.; Grus, F.H. Tears as a source of biomarkers for ocular and systemic diseases. Exp. Eye Res., 2013, 117, 126-137.
[http://dx.doi.org/10.1016/j.exer.2013.07.015] [PMID: 23880526]
[5]
Leung, E.W.; Medeiros, F.A.; Weinreb, R.N. Prevalence of ocular surface disease in glaucoma patients. J. Glaucoma, 2008, 17(5), 350-355.
[http://dx.doi.org/10.1097/IJG.0b013e31815c5f4f] [PMID: 18703943]
[6]
Mastropasqua, R.; Agnifili, L.; Fasanella, V.; Nubile, M.; Gnama, A.A.; Falconio, G.; Perri, P.; Di Staso, S.; Mariotti, C. The conjunctiva-associated lymphoid tissue in chronic ocular surface diseases. Microsc. Microanal., 2017, 23(4), 697-707.
[http://dx.doi.org/10.1017/S1431927617000538] [PMID: 28480834]
[7]
Green-Church, K.B.; Butovich, I.; Willcox, M.; Borchman, D.; Paulsen, F.; Barabino, S.; Glasgow, B.J. The international workshop on meibomian gland dysfunction: Report of the subcommittee on tear film lipids and lipid-protein interactions in health and disease. Invest. Ophthalmol. Vis. Sci., 2011, 52(4), 1979-1993.
[http://dx.doi.org/10.1167/iovs.10-6997d] [PMID: 21450916]
[8]
Gipson, I.K. Goblet cells of the conjunctiva: A review of recent findings. Prog. Retin. Eye Res., 2016, 54, 49-63.
[http://dx.doi.org/10.1016/j.preteyeres.2016.04.005] [PMID: 27091323]
[9]
Johnson, M.E.; Murphy, P.J. Changes in the tear film and ocular surface from dry eye syndrome. Prog. Retin. Eye Res., 2004, 23(4), 449-474.
[http://dx.doi.org/10.1016/j.preteyeres.2004.04.003] [PMID: 15219877]
[10]
King-Smith, P.E.; Fink, B.A.; Hill, R.M.; Koelling, K.W.; Tiffany, J.M. The thickness of the tear film. Curr. Eye Res., 2004, 29(4-5), 357-368.
[http://dx.doi.org/10.1080/02713680490516099] [PMID: 15590483]
[11]
Wang, J.; Fonn, D.; Simpson, T.L.; Jones, L. Precorneal and pre- and postlens tear film thickness measured indirectly with optical coherence tomography. Invest. Ophthalmol. Vis. Sci., 2003, 44(6), 2524-2528.
[http://dx.doi.org/10.1167/iovs.02-0731] [PMID: 12766052]
[12]
Chen, H.B.; Yamabayashi, S.; Ou, B.; Tanaka, Y.; Ohno, S.; Tsukahara, S. Structure and composition of rat precorneal tear film. A study by an in vivo cryofixation. Invest. Ophthalmol. Vis. Sci., 1997, 38(2), 381-387.
[PMID: 9040471]
[13]
Shi, X.P.; Candia, O.A. Active sodium and chloride transport across the isolated rabbit conjunctiva. Curr. Eye Res., 1995, 14(10), 927-935.
[http://dx.doi.org/10.3109/02713689508995132] [PMID: 8549158]
[14]
Klyce, S.D.; Crosson, C.E. Transport processes across the rabbit corneal epithelium: A review. Curr. Eye Res., 1985, 4(4), 323-331.
[http://dx.doi.org/[http://10.3109/02713688509025145] [PMID: 3893897]
[15]
Gouveia, S.M.; Tiffany, J.M. Human tear viscosity: An interactive role for proteins and lipids. Biochim. Biophys. Acta, 2005, 1753(2), 155-163.
[http://dx.doi.org/10.1016/j.bbapap.2005.08.023] [PMID: 16236563]
[16]
Hodges, R.R.; Dartt, D.A. Tear film mucins: Front line defenders of the ocular surface; comparison with airway and gastrointestinal tract mucins. Exp. Eye Res., 2013, 117, 62-78.
[http://dx.doi.org/10.1016/j.exer.2013.07.027] [PMID: 23954166]
[17]
Bai, Y.; Nichols, J.J. Advances in thickness measurements and dynamic visualization of the tear film using non-invasive optical approaches. Prog. Retin. Eye Res., 2017, 58, 28-44.
[http://dx.doi.org/10.1016/j.preteyeres.2017.02.002] [PMID: 28254520]
[18]
Georgiev, G.A.; Eftimov, P.; Yokoi, N. Structure-function relationship of tear film lipid layer: A contemporary perspective. Exp. Eye Res., 2017, 163, 17-28.
[http://dx.doi.org/10.1016/j.exer.2017.03.013] [PMID: 28950936]
[19]
King-Smith, P.E.; Bailey, M.D.; Braun, R.J. Four characteristics and a model of an effective Tear Film Lipid Layer (TFLL). Ocul. Surf., 2013, 11(4), 236-245.
[http://dx.doi.org/10.1016/j.jtos.2013.05.003] [PMID: 24112227]
[20]
Svitova, T.F.; Lin, M.C. Dynamic interfacial properties of human tear-lipid films and their interactions with model-tear proteins in vitro. Adv. Colloid Interface Sci., 2016, 233, 4-24.
[http://dx.doi.org/10.1016/j.cis.2015.12.009] [PMID: 26830077]
[21]
Rosenfeld, L.; Cerretani, C.; Leiske, D.L.; Toney, M.F.; Radke, C.J.; Fuller, G.G. Structural and rheological properties of meibomian lipid. Invest. Ophthalmol. Vis. Sci., 2013, 54(4), 2720-2732.
[http://dx.doi.org/10.1167/iovs.12-10987] [PMID: 23513065]
[22]
Willcox, M.D.P.; Argüeso, P.; Georgiev, G.A.; Holopainen, J.M.; Laurie, G.W.; Millar, T.J.; Papas, E.B.; Rolland, J.P.; Schmidt, T.A.; Stahl, U.; Suarez, T.; Subbaraman, L.N.; Uçakhan, O.Ö.; Jones, L. TFOS DEWS II Tear Film Report. Ocul. Surf., 2017, 15(3), 366-403.
[http://dx.doi.org/10.1016/j.jtos.2017.03.006] [PMID: 28736338]
[23]
Yokoi, N.; Yamada, H.; Mizukusa, Y.; Bron, A.J.; Tiffany, J.M.; Kato, T.; Kinoshita, S. Rheology of tear film lipid layer spread in normal and aqueous tear-deficient dry eyes. Invest. Ophthalmol. Vis. Sci., 2008, 49(12), 5319-5324.
[http://dx.doi.org/10.1167/iovs.07-1407] [PMID: 18469179]
[24]
Georgiev, G.A.; Yokoi, N.; Ivanova, S.; Tonchev, V.; Nencheva, Y.; Krastev, R. Surface relaxations as a tool to distinguish the dynamic interfacial properties of films formed by normal and diseased meibomian lipids. Soft Matter, 2014, 10(30), 5579-5588.
[http://dx.doi.org/10.1039/C4SM00758A] [PMID: 24959988]
[25]
Wolffsohn, J.S.; Arita, R.; Chalmers, R.; Djalilian, A.; Dogru, M.; Dumbleton, K.; Gupta, P.K.; Karpecki, P.; Lazreg, S.; Pult, H.; Sullivan, B.D.; Tomlinson, A.; Tong, L.; Villani, E.; Yoon, K.C.; Jones, L.; Craig, J.P. TFOS DEWS II Diagnostic methodology report. Ocul. Surf., 2017, 15(3), 539-574.
[http://dx.doi.org/10.1016/j.jtos.2017.05.001] [PMID: 28736342]
[26]
Yokoi, N.; Komuro, A. Non-invasive methods of assessing the tear film. Exp. Eye Res., 2004, 78(3), 399-407.
[http://dx.doi.org/10.1016/j.exer.2003.09.020] [PMID: 15106919]
[27]
Oguz, H.; Yokoi, N.; Kinoshita, S. The height and radius of the tear meniscus and methods for examining these parameters. Cornea, 2000, 19(4), 497-500.
[http://dx.doi.org/10.1097/00003226-200007000-00019] [PMID: 10928766]
[28]
Doane, M.G. An instrument for in vivo tear film interferometry. Optom. Vis. Sci., 1989, 66(6), 383-388.
[http://dx.doi.org/10.1097/00006324-198906000-00008] [PMID: 2771324]
[29]
Lee, S.Y.; Lee, H.; Bae, H.W.; Kim, T.I.; Kim, C.Y. Tear lipid layer thickness change and topical anti-glaucoma medication use. Optom. Vis. Sci., 2016, 93(10), 1210-1217.
[http://dx.doi.org/10.1097/OPX.0000000000000943] [PMID: 27668491]
[30]
Yokoi, N.; Mossa, F.; Tiffany, J.M.; Bron, A.J. Assessment of meibomian gland function in dry eye using meibometry. Arch. Ophthalmol., 1999, 117(6), 723-729.
[http://dx.doi.org/10.1001/archopht.117.6.723] [PMID: 10369581]
[31]
Braun, R.J.; King-Smith, P.E.; Begley, C.G.; Li, L.; Gewecke, N.R. Dynamics and function of the tear film in relation to the blink cycle. Prog. Retin. Eye Res., 2015, 45, 132-164.
[http://dx.doi.org/10.1016/j.preteyeres.2014.11.001] [PMID: 25479602]
[32]
Tomlinson, A.; Khanal, S.; Ramaesh, K.; Diaper, C.; McFadyen, A. Tear film osmolarity: Determination of a referent for dry eye diagnosis. Invest. Ophthalmol. Vis. Sci., 2006, 47(10), 4309-4315.
[http://dx.doi.org/10.1167/iovs.05-1504] [PMID: 17003420]
[33]
King-Smith, P.E.; Begley, C.G.; Braun, R.J. Mechanisms, imaging and structure of tear film breakup. Ocul. Surf., 2018, 16(1), 4-30.
[http://dx.doi.org/10.1016/j.jtos.2017.09.007] [PMID: 28935579]
[34]
Sweeney, D.F.; Millar, T.J.; Raju, S.R. Tear film stability: A review. Exp. Eye Res., 2013, 117, 28-38.
[http://dx.doi.org/[http://10.1016/j.exer.2013.08.010] [PMID: 23973716]
[35]
Napoli, P.E.; Satta, G.M.; Coronella, F.; Fossarello, M. Spectral-domain optical coherence tomography study on dynamic changes of human tears after instillation of artificial tears. Invest. Ophthalmol. Vis. Sci., 2014, 55(7), 4533-4540.
[http://dx.doi.org/10.1167/iovs.14-14666] [PMID: 24985473]
[36]
Villani, E.; Baudouin, C.; Efron, N.; Hamrah, P.; Kojima, T.; Patel, S.V.; Pflugfelder, S.C.; Zhivov, A.; Dogru, M. In vivo confocal microscopy of the ocular surface: From bench to bedside. Curr. Eye Res., 2014, 39(3), 213-231.
[http://dx.doi.org/10.3109/02713683.2013.842592] [PMID: 24215436]
[37]
Lopin, E.; Deveney, T.; Asbell, P.A. Impression cytology: Recent advances and applications in dry eye disease. Ocul. Surf., 2009, 7(2), 93-110.
[http://dx.doi.org/10.1016/S1542-0124(12)70301-4] [PMID: 19383278]
[38]
Baudouin, C.; Labbé, A.; Liang, H.; Pauly, A.; Brignole-Baudouin, F. Preservatives in eyedrops: The good, the bad and the ugly. Prog. Retin. Eye Res., 2010, 29(4), 312-334.
[http://dx.doi.org/10.1016/j.preteyeres.2010.03.001] [PMID: 20302969]
[39]
Baudouin, C. Detrimental effect of preservatives in eyedrops: Implications for the treatment of glaucoma. Acta Ophthalmol., 2008, 86(7), 716-726.
[http://dx.doi.org/10.1111/j.1755-3768.2008.01250.x] [PMID: 18537937]
[40]
Mastropasqua, L.; Agnifili, L.; Mastropasqua, R.; Fasanella, V.; Nubile, M.; Toto, L.; Carpineto, P.; Ciancaglini, M. In vivo laser scanning confocal microscopy of the ocular surface in glaucoma. Microsc. Microanal., 2014, 20(3), 879-894.
[http://dx.doi.org/10.1017/S1431927614000324] [PMID: 24576766]
[41]
Mastropasqua, L.; Agnifili, L.; Fasanella, V.; Curcio, C.; Ciabattoni, C.; Mastropasqua, R.; Toto, L.; Ciancaglini, M. Conjunctival goblet cells density and preservative-free tafluprost therapy for glaucoma: An in vivo confocal microscopy and impression cytology study. Acta Ophthalmol., 2013, 91(5), e397-e405.
[http://dx.doi.org/10.1111/aos.12131] [PMID: 23601909]
[42]
Ciancaglini, M.; Carpineto, P.; Agnifili, L.; Nubile, M.; Fasanella, V.; Lanzini, M.; Calienno, R.; Mastropasqua, L. An in vivo confocal microscopy and impression cytology analysis of preserved and unpreserved levobunolol-induced conjunctival changes. Eur. J. Ophthalmol., 2008, 18(3), 400-407.
[http://dx.doi.org/10.1177/112067210801800314] [PMID: 18465723]
[43]
Agnifili, L.; Fasanella, V.; Mastropasqua, R.; Frezzotti, P.; Curcio, C.; Brescia, L.; Marchini, G. In vivo goblet cell density as a potential indicator of glaucoma filtration surgery outcome. Invest. Ophthalmol. Vis. Sci., 2016, 57(7), 2928-2935.
[http://dx.doi.org/10.1167/iovs.16-19257] [PMID: 27249666]
[44]
Broadway, D.C.; Grierson, I.; O’Brien, C.; Hitchings, R.A. Adverse effects of topical antiglaucoma medication. I. The conjunctival cell profile. Arch. Ophthalmol., 1994, 112(11), 1437-1445.
[http://dx.doi.org/10.1001/archopht.1994.01090230051020] [PMID: 7980133]
[45]
Pisella, P.J.; Debbasch, C.; Hamard, P.; Creuzot-Garcher, C.; Rat, P.; Brignole, F.; Baudouin, C. Conjunctival proinflammatory and proapoptotic effects of latanoprost and preserved and unpreserved timolol: An ex vivo and in vitro study. Invest. Ophthalmol. Vis. Sci., 2004, 45(5), 1360-1368.
[http://dx.doi.org/10.1167/iovs.03-1067] [PMID: 15111589]
[46]
Agnifili, L.; Mastropasqua, R.; Fasanella, V.; Brescia, L.; Scatena, B.; Oddone, F.; Mastropasqua, L. Meibomian gland features and conjunctival goblet cell density in glaucomatous patients controlled with prostaglandin/timolol fixed combinations: A case control, cross-sectional study. J. Glaucoma, 2018, 27(4), 364-370.
[http://dx.doi.org/10.1097/IJG.0000000000000899] [PMID: 29401160]
[47]
Moreno, M.; Villena, A.; Cabarga, C.; Sanchez-Font, E.; Garcia-Campos, J. Impression cytology of the conjunctival epithelium after antiglaucomatous treatment with latanoprost. Eur. J. Ophthalmol., 2003, 13(6), 553-559.
[http://dx.doi.org/10.1177/112067210301300608] [PMID: 12948314]
[48]
Chung, W.C.; Ryu, S.H.; Sun, H.; Zeldin, D.C.; Koo, J.S. CREB mediates prostaglandin F2alpha-induced MUC5AC overexpression. J. Immunol., 2009, 182(4), 2349-2356.
[http://dx.doi.org/10.4049/jimmunol.0713637] [PMID: 19201889]
[49]
Mastropasqua, L.; Agnifili, L.; Mastropasqua, R.; Fasanella, V. Conjunctival modifications induced by medical and surgical therapies in patients with glaucoma. Curr. Opin. Pharmacol., 2013, 13(1), 56-64.
[http://dx.doi.org/10.1016/j.coph.2012.10.002] [PMID: 23127698]
[50]
Frezzotti, P.; Fogagnolo, P.; Haka, G.; Motolese, I.; Iester, M.; Bagaglia, S.A.; Mittica, P.; Menicacci, C.; Rossetti, L.; Motolese, E. In vivo confocal microscopy of conjunctiva in preservative-free timolol 0.1% gel formulation therapy for glaucoma. Acta Ophthalmol., 2014, 92(2), e133-e140.
[http://dx.doi.org/10.1111/aos.12261] [PMID: 24020826]
[51]
Arita, R.; Itoh, K.; Maeda, S.; Maeda, K.; Furuta, A.; Tomidokoro, A.; Aihara, M.; Amano, S. Comparison of the long-term effects of various topical antiglaucoma medications on meibomian glands. Cornea, 2012, 31(11), 1229-1234.
[http://dx.doi.org/10.1097/ICO.0b013e31823f8e7d] [PMID: 22406943]
[52]
Arita, R.; Itoh, K.; Maeda, S.; Maeda, K.; Furuta, A.; Tomidokoro, A.; Aihara, M.; Amano, S. Effects of long-term topical anti-glaucoma medications on meibomian glands. Graefes Arch. Clin. Exp. Ophthalmol., 2012, 250(8), 1181-1185.
[http://dx.doi.org/10.1007/s00417-012-1943-6] [PMID: 22349978]
[53]
Agnifili, L.; Fasanella, V.; Costagliola, C.; Ciabattoni, C.; Mastropasqua, R.; Frezzotti, P.; Mastropasqua, L. In vivo confocal microscopy of meibomian glands in glaucoma. Br. J. Ophthalmol., 2013, 97(3), 343-349.
[http://dx.doi.org/10.1136/bjophthalmol-2012-302597] [PMID: 23269683]
[54]
Fasanella, V.; Agnifili, L.; Mastropasqua, R.; Brescia, L.; Di Staso, F.; Ciancaglini, M.; Mastropasqua, L. In vivo laser scanning confocal microscopy of human meibomian glands in aging and ocular surface diseases. BioMed Res. Int., 2016.20167432131
[http://dx.doi.org/10.1155/2016/7432131] [PMID: 27047965]
[55]
Uzunosmanoglu, E.; Mocan, M.C.; Kocabeyoglu, S.; Karakaya, J.; Irkec, M. Meibomian Gland Dysfunction in Patients Receiving Long-Term Glaucoma Medications. Cornea, 2016, 35(8), 1112-1116.
[http://dx.doi.org/10.1097/ICO.0000000000000838] [PMID: 27055218]
[56]
Nuzzi, R.; Vercelli, A.; Finazzo, C.; Cracco, C. Conjunctiva and subconjunctival tissue in primary open-angle glaucoma after long-term topical treatment: An immunohistochemical and ultrastructural study. Graefes Arch. Clin. Exp. Ophthalmol., 1995, 233(3), 154-162.
[http://dx.doi.org/10.1007/BF00166608] [PMID: 7758983]
[57]
Francoz, M.; Karamoko, I.; Baudouin, C.; Labbé, A. Ocular surface epithelial thickness evaluation with spectral-domain optical coherence tomography. Invest. Ophthalmol. Vis. Sci., 2011, 52(12), 9116-9123.
[http://dx.doi.org/10.1167/iovs.11-7988] [PMID: 22025572]
[58]
Martone, G.; Frezzotti, P.; Tosi, G.M.; Traversi, C.; Mittica, V.; Malandrini, A.; Pichierri, P.; Balestrazzi, A.; Motolese, P.A.; Motolese, I.; Motolese, E. An in vivo confocal microscopy analysis of effects of topical antiglaucoma therapy with preservative on corneal innervation and morphology. Am. J. Ophthalmol., 2009, 147(4), 725-735.e1.
[http://dx.doi.org/10.1016/j.ajo.2008.10.019] [PMID: 19181302]
[59]
Mastropasqua, R.; Agnifili, L.; Fasanella, V.; Curcio, C.; Brescia, L.; Lanzini, M.; Fresina, M.; Mastropasqua, L.; Marchini, G. Corneoscleral limbus in glaucoma patients: In vivo confocal microscopy and immunocytological study. Invest. Ophthalmol. Vis. Sci., 2015, 56(3), 2050-2058.
[http://dx.doi.org/10.1167/iovs.14-15890] [PMID: 25744981]
[60]
Levin, M.H.; Verkman, A.S. Aquaporin-dependent water permeation at the mouse ocular surface: In vivo microfluorimetric measurements in cornea and conjunctiva. Invest. Ophthalmol. Vis. Sci., 2004, 45(12), 4423-4432.
[http://dx.doi.org/10.1167/iovs.04-0816] [PMID: 15557451]
[61]
Gipson, I.K.; Yankauckas, M.; Spurr-Michaud, S.J.; Tisdale, A.S.; Rinehart, W. Characteristics of a glycoprotein in the ocular surface glycocalyx. Invest. Ophthalmol. Vis. Sci., 1992, 33(1), 218-227.
[PMID: 1370440]
[62]
Sharma, A. Breakup and dewetting of the corneal mucus layer. An update. Adv. Exp. Med. Biol., 1998, 438, 273-280.
[http://dx.doi.org/10.1007/978-1-4615-5359-5_39] [PMID: 9634897]
[63]
Murube, J. Tear osmolarity. Ocul. Surf., 2006, 4(2), 62-73.
[http://dx.doi.org/10.1016/S1542-0124(12)70028-9] [PMID: 16681077]
[64]
Sullivan, B.D.; Whitmer, D.; Nichols, K.K.; Tomlinson, A.; Foulks, G.N.; Geerling, G.; Pepose, J.S.; Kosheleff, V.; Porreco, A.; Lemp, M.A. An objective approach to dry eye disease severity. Invest. Ophthalmol. Vis. Sci., 2010, 51(12), 6125-6130.
[http://dx.doi.org/10.1167/iovs.10-5390] [PMID: 20631232]
[65]
Baudouin, C.; Aragona, P.; Messmer, E.M.; Tomlinson, A.; Calonge, M.; Boboridis, K.G.; Akova, Y.A.; Geerling, G.; Labetoulle, M.; Rolando, M. Role of hyperosmolarity in the pathogenesis and management of dry eye disease: Proceedings of the OCEAN group meeting. Ocul. Surf., 2013, 11(4), 246-258.
[http://dx.doi.org/10.1016/j.jtos.2013.07.003] [PMID: 24112228]
[66]
Yokoi, N.; Georgiev, G.A.; Kato, H.; Komuro, A.; Sonomura, Y.; Sotozono, C.; Tsubota, K.; Kinoshita, S. Classification of fluorescein breakup patterns: A novel method of differential diagnosis for dry eye. Am. J. Ophthalmol., 2017, 180, 72-85.
[http://dx.doi.org/10.1016/j.ajo.2017.05.022] [PMID: 28579061]
[67]
Labbé, A.; Terry, O.; Brasnu, E.; Van Went, C.; Baudouin, C. Tear film osmolarity in patients treated for glaucoma or ocular hypertension. Cornea, 2012, 31(9), 994-999.
[http://dx.doi.org/10.1097/ICO.0b013e31823f8cb6] [PMID: 22710490]
[68]
(No authors listed). The definition and classification of dry eye disease: Report of the definition and classification subcommittee of the international dry eye workshop. Ocul. Surf., 2007, 5, 75-92.
[http://dx.doi.org/10.1016/S1542-0124(12)70081-2] [PMID: 17508116]
[69]
Manni, G.; Centofanti, M.; Oddone, F.; Parravano, M.; Bucci, M.G. Interleukin-1beta tear concentration in glaucomatous and ocular hypertensive patients treated with preservative-free nonselective beta-blockers. Am. J. Ophthalmol., 2005, 139(1), 72-77.
[http://dx.doi.org/10.1016/j.ajo.2004.08.028] [PMID: 15652830]
[70]
Tomić, M.; Kaštelan, S.; Soldo, K.M.; Salopek-Rabatić, J. Influence of BAK-preserved prostaglandin analog treatment on the ocular surface health in patients with newly diagnosed primary open-angle glaucoma. BioMed Res. Int., 2013, 2013603782
[http://dx.doi.org/10.1155/2013/603782] [PMID: 23971041]
[71]
Valente, C.; Iester, M.; Corsi, E.; Rolando, M. Symptoms and signs of tear film dysfunction in glaucomatous patients. J. Ocul. Pharmacol. Ther., 2011, 27(3), 281-285.
[http://dx.doi.org/10.1089/jop.2010.0133] [PMID: 21557633]
[72]
Chung, S.H.; Lee, S.K.; Cristol, S.M.; Lee, E.S.; Lee, D.W.; Seo, K.Y.; Kim, E.K. Impact of short-term exposure of commercial eyedrops preserved with benzalkonium chloride on precorneal mucin. Mol. Vis., 2006, 12, 415-421.
[PMID: 16688112]
[73]
Liu, W.; Li, H.; Lu, D.; Liang, J.; Xing, X.; Liu, A.; Zhao, S.; Li, X.; Ji, J. The tear fluid mucin 5AC change of primary angle-closure glaucoma patients after short-term medications and phacotrabeculectomy. Mol. Vis., 2010, 16, 2342-2346.
[PMID: 21139981]
[74]
Phillips, T.E.; Stanley, C.M.; Wilson, J. The effect of 16,16- dimethyl postaglandin E2 on proliferation of an intestinal goblet cell line and its synthesis and secretion of mucin glycoproteins. Prostaglandins Leukot.\. Essent. Fatty Acids, 1993, 48, 423-428.
[http://dx.doi.org/10.1016/0952-3278(93)90047-Z] [PMID: 8341719]
[75]
Rose, M.C.; Voynow, J.A. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol. Rev., 2006, 86(1), 245-278.
[http://dx.doi.org/10.1152/physrev.00010.2005] [PMID: 16371599]
[76]
Uusitalo, H.; Chen, E.; Pfeiffer, N.; Brignole-Baudouin, F.; Kaarniranta, K.; Leino, M.; Puska, P.; Palmgren, E.; Hamacher, T.; Hofmann, G.; Petzold, G.; Richter, U.; Riedel, T.; Winter, M.; Ropo, A. Switching from a preserved to a preservative-free prostaglandin preparation in topical glaucoma medication. Acta Ophthalmol., 2010, 88(3), 329-336.
[http://dx.doi.org/10.1111/j.1755-3768.2010.01907.x] [PMID: 20546237]
[77]
Baudouin, C.; Pisella, P.J.; Fillacier, K.; Goldschild, M.; Becquet, F.; De Saint Jean, M.; Béchetoille, A. Ocular surface inflammatory changes induced by topical antiglaucoma drugs: Human and animal studies. Ophthalmology, 1999, 106(3), 556-563.
[http://dx.doi.org/10.1016/S0161-6420(99)90116-1] [PMID: 10080214]
[78]
Terai, N.; Müller-Holz, M.; Spoerl, E.; Pillunat, L.E. Short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects. Clin. Ophthalmol., 2011, 5, 517-525.
[http://dx.doi.org/10.2147/OPTH.S18849] [PMID: 21573041]
[79]
Thygesen, J.; Aaen, K.; Theodorsen, F.; Kessing, S.V.; Prause, J.U. Short-term effect of latanoprost and timolol eye drops on tear fluid and the ocular surface in patients with primary open-angle glaucoma and ocular hypertension. Acta Ophthalmol. Scand., 2000, 78(1), 37-44.
[http://dx.doi.org/10.1034/j.1600-0420.2000.078001037.x] [PMID: 10726786]
[80]
Mathers, W.D.; Lane, J.A. Meibomian glands lipids, evaporation and tear film stability. Lacrimal Gland, Tear film and DE Syndromes 2, Sullivan, D.A.; Dartt, D.A.; Meneray, M.A., Eds.; Plenum Press: New York. 1998, Vol. 438, pp. 349-360.
[http://dx.doi.org/10.1007/978-1-4615-5359-5_50]
[81]
Lee, S.Y.; Wong, T.T.; Chua, J.; Boo, C.; Soh, Y.F.; Tong, L. Effect of chronic anti-glaucoma medications and trabeculectomy on tear osmolarity. Eye (Lond.), 2013, 27(10), 1142-1150.
[http://dx.doi.org/10.1038/eye.2013.144] [PMID: 23846375]
[82]
Georgiev, G.A.; Eftimov, P.; Yokoi, N. Structure-function relationship of tear film lipid layer: A contemporary perspective. Exp. Eye Res., 2017, 163, 17-28.
[http://dx.doi.org/10.1016/j.exer.2017.03.013] [PMID: 28950936]
[83]
Mochizuki, H.; Yamada, M.; Hatou, S.; Tsubota, K. Turnover rate of tear-film lipid layer determined by fluorophotometry. Br. J. Ophthalmol., 2009, 93(11), 1535-1538.
[http://dx.doi.org/10.1136/bjo.2008.156828] [PMID: 19692365]
[84]
Georgiev, G.A.; Yokoi, N.; Koev, K.; Kutsarova, E.; Ivanova, S.; Kyumurkov, A.; Jordanova, A.; Krastev, R.; Lalchev, Z. Surface chemistry study of the interactions of benzalkonium chloride with films of meibum, corneal cells lipids, and whole tears. Invest. Ophthalmol. Vis. Sci., 2011, 52(7), 4645-4654.
[http://dx.doi.org/10.1167/iovs.10-6271] [PMID: 21474774]
[85]
Georgiev, G.A.; Yokoi, N.; Ivanova, S.; Krastev, R.; Lalchev, Z. Surface chemistry study of the interactions of pharmaceutical ingredients with human meibum films. Invest. Ophthalmol. Vis. Sci., 2012, 53(8), 4605-4615.
[http://dx.doi.org/10.1167/iovs.12-9907] [PMID: 22695955]
[86]
Ishibashi, T.; Yokoi, N.; Kinoshita, S. Comparison of the short-term effects on the human corneal surface of topical timolol maleate with and without benzalkonium chloride. J. Glaucoma, 2003, 12(6), 486-490.
[http://dx.doi.org/10.1097/00061198-200312000-00008] [PMID: 14646684]
[87]
King-Smith, P.E.; Hinel, E.A.; Nichols, J.J. Application of a novel interferometric method to investigate the relation between lipid layer thickness and tear film thinning. Invest. Ophthalmol. Vis. Sci., 2010, 51(5), 2418-2423.
[http://dx.doi.org/10.1167/iovs.09-4387] [PMID: 20019370]
[88]
Eom, Y.; Lee, J.S.; Kang, S.Y.; Kim, H.M.; Song, J.S. Correlation between quantitative measurements of tear film lipid layer thickness and meibomian gland loss in patients with obstructive meibomian gland dysfunction and normal controls. Am. J. Ophthalmol., 2013, 155(6), 1104-1110.e2.
[http://dx.doi.org/10.1016/j.ajo.2013.01.008] [PMID: 23465270]
[89]
Stern, M.E.; Beuerman, R.W.; Fox, R.I.; Gao, J.; Mircheff, A.K.; Pflugfelder, S.C. The pathology of dry eye: The interaction between the ocular surface and lacrimal glands. Cornea, 1998, 17(6), 584-589.
[http://dx.doi.org/10.1097/00003226-199811000-00002] [PMID: 9820935]
[90]
Ciancaglini, M.; Carpineto, P.; Agnifili, L.; Nubile, M.; Fasanella, V.; Mattei, P.A.; Mastropasqua, L. Conjunctival characteristics in primary open-angle glaucoma and modifications induced by trabeculectomy with mitomycin C: An in vivo confocal microscopy study. Br. J. Ophthalmol., 2009, 93(9), 1204-1209.
[http://dx.doi.org/10.1136/bjo.2008.152496] [PMID: 19570768]
[91]
Agnifili, L.; Carpineto, P.; Fasanella, V.; Mastropasqua, R.; Zappacosta, A.; Di Staso, S.; Costagliola, C.; Mastropasqua, L. Conjunctival findings in hyperbaric and low-tension glaucoma: An in vivo confocal microscopy study. Acta Ophthalmol., 2012, 90(2), e132-e137.
[http://dx.doi.org/10.1111/j.1755-3768.2011.02255.x] [PMID: 21955651]
[92]
Pieragostino, D.; Agnifili, L.; Fasanella, V.; D’Aguanno, S.; Mastropasqua, R.; Di Ilio, C.; Sacchetta, P.; Urbani, A.; Del Boccio, P. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol. Biosyst., 2013, 9(6), 1108-1116.
[http://dx.doi.org/10.1039/c3mb25463a] [PMID: 23580065]
[93]
Kaeslin, M.A.; Killer, H.E.; Fuhrer, C.A.; Zeleny, N.; Huber, A.R.; Neutzner, A. Changes to the Aqueous Humor Proteome during Glaucoma. PLoS One, 2016, 11(10)e0165314
[http://dx.doi.org/10.1371/journal.pone.0165314] [PMID: 27788204]
[94]
Van Haeringen, N.J. The renin-angiotensin system in the human eye. Br. J. Ophthalmol., 1996, 80(2), 99-100.
[http://dx.doi.org/10.1136/bjo.80.2.99] [PMID: 8814761]
[95]
Borovic, D.; Bendelic, E.; Chiseliţă, D. [Study of kini-kallikrein and renin--angiotensin systems in patients with primary open angle glaucoma Oftalmologia, 2009, 53(2), 61-68.
[PMID: 19697842]
[96]
Pieragostino, D.; Bucci, S.; Agnifili, L.; Fasanella, V.; D’Aguanno, S.; Mastropasqua, A.; Ciancaglini, M.; Mastropasqua, L.; Di Ilio, C.; Sacchetta, P.; Urbani, A.; Del Boccio, P. Differential protein expression in tears of patients with primary open angle and pseudoexfoliative glaucoma. Mol. Biosyst., 2012, 8(4), 1017-1028.
[http://dx.doi.org/10.1039/C1MB05357D] [PMID: 22124706]
[97]
Lopilly Park, H.Y.; Kim, J.H.; Lee, K.M.; Park, C.K. Effect of prostaglandin analogues on tear proteomics and expression of cytokines and matrix metalloproteinases in the conjunctiva and cornea. Exp. Eye Res., 2012, 94(1), 13-21.
[http://dx.doi.org/10.1016/j.exer.2011.10.017] [PMID: 22067128]
[98]
Sahay, P.; Rao, A.; Padhy, D.; Sarangi, S.; Das, G.; Reddy, M.M.; Modak, R. Functional activity of matrix metalloproteinases 2 and 9 in tears of patients with glaucoma. Invest. Ophthalmol. Vis. Sci., 2017, 58(6), BIO106-BIO113.
[http://dx.doi.org/10.1167/iovs.17-21723] [PMID: 28586796]
[99]
Malvitte, L.; Montange, T.; Vejux, A.; Baudouin, C.; Bron, A.M.; Creuzot-Garcher, C.; Lizard, G. Measurement of inflammatory cytokines by multicytokine assay in tears of patients with glaucoma topically treated with chronic drugs. Br. J. Ophthalmol., 2007, 91(1), 29-32.
[http://dx.doi.org/10.1136/bjo.2006.101485] [PMID: 16943231]
[100]
Manni, G.; Centofanti, M.; Oddone, F.; Parravano, M.; Bucci, M.G. Interleukin-1beta tear concentration in glaucomatous and ocular hypertensive patients treated with preservative-free nonselective beta-blockers. Am. J. Ophthalmol., 2005, 139(1), 72-77.
[http://dx.doi.org/10.1016/j.ajo.2004.08.028] [PMID: 15652830]
[101]
Wong, T.T.; Zhou, L.; Li, J.; Tong, L.; Zhao, S.Z.; Li, X.R.; Yu, S.J.; Koh, S.K.; Beuerman, R.W. Proteomic profiling of inflammatory signaling molecules in the tears of patients on chronic glaucoma medication. Invest. Ophthalmol. Vis. Sci., 2011, 52(10), 7385-7391.
[http://dx.doi.org/10.1167/iovs.10-6532] [PMID: 21697136]
[102]
Ghaffariyeh, A.; Honarpisheh, N.; Shakiba, Y.; Puyan, S.; Chamacham, T.; Zahedi, F.; Zarrineghbal, M. Brain-derived neurotrophic factor in patients with normal-tension glaucoma. Optometry, 2009, 80(11), 635-638.
[http://dx.doi.org/10.1016/j.optm.2008.09.014] [PMID: 19861219]
[103]
Roedl, J.B.; Bleich, S.; Schlötzer-Schrehardt, U.; von Ahsen, N.; Kornhuber, J.; Naumann, G.O.; Kruse, F.E.; Jünemann, A.G. Increased homocysteine levels in tear fluid of patients with primary open-angle glaucoma. Ophthalmic Res., 2008, 40(5), 249-256.
[http://dx.doi.org/10.1159/000127832] [PMID: 18437035]
[104]
Neves Mendes, C.R.; Hida, R.Y.; Kasahara, N. Ocular surface changes in eyes with glaucoma filtering blebs. Curr. Eye Res., 2012, 37(4), 309-311.
[http://dx.doi.org/10.3109/02713683.2011.635400] [PMID: 22440162]
[105]
Ji, H.; Zhu, Y.; Zhang, Y.; Li, Z.; Ge, J.; Zhuo, Y. Dry eye disease in patients with functioning filtering blebs after trabeculectomy. PLoS One, 2016, 11(3)e0152696
[http://dx.doi.org/10.1371/journal.pone.0152696] [PMID: 27032098]
[106]
Liang, S.Y-W.; Lee, G.A.; Whitehead, K. Histopathology of a functioning mitomycin-C trabeculectomy. Clin. Exp. Ophthalmol., 2009, 37(3), 316-319.
[http://dx.doi.org/10.1111/j.1442-9071.2009.02023.x] [PMID: 19459872]
[107]
Wilson, S.E.; Netto, M.; Ambrósio, R. Jr Corneal cells: Chatty in development, homeostasis, wound healing, and disease. Am. J. Ophthalmol., 2003, 136(3), 530-536.
[http://dx.doi.org/10.1016/S0002-9394(03)00085-0] [PMID: 12967809]
[108]
Rodriguez, A.E.; Rodriguez-Prats, J.L.; Hamdi, I.M.; Galal, A.; Awadalla, M.; Alio, J.L. Comparison of goblet cell density after femtosecond laser and mechanical microkeratome in LASIK. Invest. Ophthalmol. Vis. Sci., 2007, 48(6), 2570-2575.
[http://dx.doi.org/10.1167/iovs.06-1259] [PMID: 17525186]
[109]
Amar, N.; Labbé, A.; Hamard, P.; Dupas, B.; Baudouin, C. Filtering blebs and aqueous pathway an immunocytological and in vivo confocal microscopy study. Ophthalmology, 2008, 115(7), 1154-1161.e4.
[http://dx.doi.org/10.1016/j.ophtha.2007.10.024] [PMID: 18096232]
[110]
Skalicky, S.E.; Goldberg, I.; McCluskey, P. Ocular surface disease and quality of life in patients with glaucoma. Am. J. Ophthalmol., 2012, 153(1), 1-9.e2.
[http://dx.doi.org/10.1016/j.ajo.2011.05.033] [PMID: 21872203]
[111]
Anwar, Z.; Wellik, S.R.; Galor, A. Glaucoma therapy and ocular surface disease: Current literature and recommendations. Curr. Opin. Ophthalmol., 2013, 24(2), 136-143.
[http://dx.doi.org/10.1097/ICU.0b013e32835c8aba] [PMID: 23542350]
[112]
Villani, E.; Sacchi, M.; Magnani, F.; Nicodemo, A.; Williams, S.E.; Rossi, A.; Ratiglia, R.; De Cillà, S.; Nucci, P. The ocular surface in medically controlled glaucoma: An in vivo confocal study. Invest. Ophthalmol. Vis. Sci., 2016, 57(3), 1003-1010.
[http://dx.doi.org/10.1167/iovs.15-17455] [PMID: 26962696]
[113]
Mathews, P.M.; Ramulu, P.Y.; Friedman, D.S.; Utine, C.A.; Akpek, E.K. Evaluation of ocular surface disease in patients with glaucoma. Ophthalmology, 2013, 120(11), 2241-2248.
[http://dx.doi.org/10.1016/j.ophtha.2013.03.045] [PMID: 23714318]
[114]
Mastropasqua, R.; Agnifili, L.; Fasanella, V.; Lappa, A.; Brescia, L.; Lanzini, M.; Oddone, F.; Perri, P.; Mastropasqua, L. In vivo distribution of corneal epithelial dendritic cells in patients with glaucoma. Invest. Ophthalmol. Vis. Sci., 2016, 57(14), 5996-6002.
[http://dx.doi.org/10.1167/iovs.16-20333] [PMID: 27820631]
[115]
Rossi, G.C.; Tinelli, C.; Pasinetti, G.M.; Milano, G.; Bianchi, P.E. Dry eye syndrome-related quality of life in glaucoma patients. Eur. J. Ophthalmol., 2009, 19(4), 572-579.
[http://dx.doi.org/10.1177/112067210901900409] [PMID: 19551671]
[116]
Montés-Micó, R.; Cerviño, A.; Ferrer-Blasco, T.; García-Lázaro, S.; Madrid-Costa, D. The tear film and the optical quality of the eye. Ocul. Surf., 2010, 8(4), 185-192.
[http://dx.doi.org/10.1016/S1542-0124(12)70233-1] [PMID: 20964981]


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