Metabolomics-based Approach to Pharmacotherapy Personalization: Advantages and Limitations

(E-pub Abstract Ahead of Print)

Author(s): Dmitry Maslov*, Elena Balashova, Oxana Trifonova, Petr Lokhov.

Journal Name: Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics)


Background: A patient-focused approach to treatment, where individual characteristics provide the selection of optimal medication strategy for a particular patient, is the trend of current clinical therapy. An application of advanced “omics” technologies, which enable detect the inter-individual variability in genomic, transcriptomic, proteomic, and metabolomic levels is a perspective way to achieve such personalization. Objective: In this review, the advantages of metabolomics-based approach as one of the most promising and perspective for individualization of pharmacotherapy are demonstrated. This approach provides a prediction of the inter-individual variability in drug response and allows monitoring effectiveness of drug treatment, correcting it in account of individual parameters of patients. Method: Comparative analysis of metabolomics-based approach and the current methods of drug treatment personalization are carried out. Result: Advantages and limitations of the metabolomics-based approach were identified and discussed. Conclusion: A perspective ways for solution of limitations of the metabolomics-based approach are considered.

Keywords: metabolomics, pharmacometabolomics, pharmacogenomics, personalized medicine, mass spectrometry, metabolomics-based approach.

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(E-pub Abstract Ahead of Print)
DOI: 10.2174/1875692116666181008144905
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