Background: Herein we disclosed a clean and sustainable, one pot, multicomponent protocol
for the synthesis of Benzopyrimido[4,5-b]quinoline in glycerol in the presence of malic acid.
Methods: The reported strategy eliminates the use of hazardous transition metal catalysts, acid, base
and volatile organic solvents, which negatively affect the environment. In addition present methodology
has advantages of mild reaction conditions, wide substrate scope, operational simplicity, easy
workup, cost effectiveness and high yields of desired products.
Conclusion: We have presented an efficient malic acid promoted, environmentally benign synthetic
route to highly functionalized benzo[f]pyrimido[4,5-b]quinoline derivatives.