Malic Acid as Bioorganocatalyst: Sustainable, One-pot and Multicomponent Synthesis of Benzopyrimido[4,5-b]quinoline in Biodegradable Glycerol

Title:Malic Acid as Bioorganocatalyst: Sustainable, One-pot and Multicomponent Synthesis of Benzopyrimido[4,5-b]quinoline in Biodegradable Glycerol

Volume: 5 Issue: 3

Author(s): Akhilesh Kumar, Pragati Rai, Vijay B. Yadav, Hozeyfa Sagir and I. R. Siddiqui*

Affiliation:

• Laboratory of Green Synthesis, Department of Chemistry University of Allahabad, Allahabad-211002,India

Keywords: 5-b]quinolone, benzopyrimido, cost effectiveness, malic acid, multicomponent, yields.

Abstract: Background: Herein we disclosed a clean and sustainable, one pot, multicomponent protocol for the synthesis of Benzopyrimido[4,5-b]quinoline in glycerol in the presence of malic acid.

Methods: The reported strategy eliminates the use of hazardous transition metal catalysts, acid, base and volatile organic solvents, which negatively affect the environment. In addition present methodology has advantages of mild reaction conditions, wide substrate scope, operational simplicity, easy workup, cost effectiveness and high yields of desired products.

Conclusion: We have presented an efficient malic acid promoted, environmentally benign synthetic route to highly functionalized benzo[f]pyrimido[4,5-b]quinoline derivatives.

Cite this article as:

Kumar Akhilesh, Rai Pragati, Yadav B. Vijay, Sagir Hozeyfa and Siddiqui I. R.*, Malic Acid as Bioorganocatalyst: Sustainable, One-pot and Multicomponent Synthesis of Benzopyrimido[4,5-b]quinoline in Biodegradable Glycerol, Current Organocatalysis 2018; 5 (3) . https://dx.doi.org/10.2174/2213337205666181008103213