The present study reported the preparation of a novel mutual prodrug containing meso-tetra
(m-hydroxy phenyl) chlorin (m-THPC), PEG and folate. The folate receptor (FR) targeting compound
is a water-soluble chemical incorporating a hydrophilic PEG spacer unit and a reducible selfimmolative
disulfide-based linker system between the FR-targeting ligand and the chlorin. The m-
THPC-s-s-PEG-Folate was proved to release the parent drug and exhibited significant targeting effects
on HeLa cells. In addition, the redox-responsive folate targeting photosensitizer m-THPC-s-s-PEG-Folate
showed slightly higher phototoxicity than m-THPC-PEG-Folate for HeLa cells.
Keywords: m-THPC, folate, disulfide, tumor, PEG, releasable.
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