Insulin resistance plays a key role in cardiovascular complications associated with diabetes
mellitus and hypertensive disorders. In states of insulin resistance several circulating factors may contribute
to a defective insulin sensitivity in different tissues, including the vasculature. One of these factors
influencing the vascular insulin resistance are the extracellular vesicles. The extracellular vesicles
include exosomes, microvesicles, and apoptotic bodies which are released to the circulation by different
vascular cells. Since the cargo of extracellular vesicles seems to be altered in metabolic complications
associated with insulin resistance, these vesicles may be candidates contributing to vascular insulin resistance.
Despite the studies linking insulin resistance signalling pathways with the vascular effect of
extracellular vesicles, the involvement of these structures in vascular insulin resistance is a phenomenon
that remains unclear.
Keywords: insulin, insulin resistance, endothelium, vascular, extracellular vesicles
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