Complication in the hepatic system is a major concern for human being. To control and keep the hepatic
system healthy, a number of measures, including drug treatments are considered. Diterpenes are essential
oils having promising antioxidant and cytotoxic properties along with their genotoxic and mutagenic effects.
These agents are good targets for health promotion, especially in the light of their potential organo-protectivity.
We searched in the databases, PUBMED and SCIENCE DIRECT from June 2011 to June 2016 for publishing
evidence on diterpenes and their effects on hepatic system. After sorting the data, activity-wise findings are discussed
in this current article. The results suggest that diterpenes have hepatoprotectivity property via antioxidant
and anti-inflammatory, antimicrobial, anticancer/antitumor, hypolipidemic, anti-apoptosis, autophagic, antimetastasize,
anti-proliferating, anti-fibrosis as well as receptor and serum biomarkers mediated pathways. On the
other hand, hepatoxic effects of diterpenes are also accounted with cytotoxicity, apoptotic cell death and downregulation
of cytochrome P450 systems. A number of important diterpenes have been reported in the literatures
that act on the hepatic system. Some of them exert toxic effects on the liver, especially in rodent model. Hence,
more extensive researches are recommended that will highlight their mechanism of action on the liver.