Review on the Role of the Metal Catalysts in the Synthesis of Pharmacologically Important Quinoline Substrate

Author(s): Akhil Mahajan , Tejpal Singh Chundawat* .

Journal Name: Mini-Reviews in Organic Chemistry

Volume 16 , Issue 7 , 2019

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Abstract:

Quinoline stands out amongst the most essential N-based heterocyclic biologically active compounds. Friedlieb Ferdinand Runge was first to isolate quinoline from coal tar in 1834. Chemical component, quinine found in the bark of cinchona tree was used for treatment of malaria in the year of 1820. Quinoline derivatives have been found to exhibit different therapeutic activities such as antimalarial, antibacterial, antifungal, antiplatelet, anticancer, antitubercular, etc. There are a couple of promising compounds with the Quinoline skeleton like Pamaquine, Chloroquine, Tafenoquine, Bulaquine, Quinine and Mefloquine which show Antimalarial activity. All the methodologies in last decade had been covered to provide a comprehensive review on the development of Quinoline analogs using metal catalyst. Since quinoline and its auxiliaries have extensive pharmacological activities and are moreover utilized as ligands in various metal complexes, various procedures have been now and again reported for their synthesis. We have tried here undertaking to collect a huge part of the procedure that has been represented in the written work by use of metal driving force. This review will be especially profitable to the examiner in quick exploring and developing another ecopleasing, capable and judicious protocol.

Keywords: Metal catalysts, bioactive compounds, quinoline, cinchona tree, coupling reactions, antimalarial activity.

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Article Details

VOLUME: 16
ISSUE: 7
Year: 2019
Page: [631 - 652]
Pages: 22
DOI: 10.2174/1570193X15666181001142122
Price: $58

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