Natural product modified organocatalysts have gained attention due to their environmentally
benign and biodegradable nature and as a result, these are now becoming powerful tools for the
construction of simple to complex molecules with new concepts and designs. In the recent past,
Camphorsulfonic Acid (CSA) has gained considerable attention as an efficient organocatalyst for the
synthesis of various organic scaffolds with potential pharmacological interest. Camphorsulfonic acid
(or Reychler’s acid) is inexpensive, commercially available, stable, non-toxic, reusable organocatalyst
which can catalyze a variety of organic transformations such as many multi-component reactions, organic
named reactions and the synthesis of various biologically promising heterocyclic compounds.
The present review summarizes the camphorsulfonic acid-catalyzed synthesis of bioactive heterocycles
reported so far.
Keywords: Camphorsulfonic acid, reychler's acid, organocatalyst, organic synthesis, bioactive heterocycles, piperidines.
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