Targeting PD-L1 Protein: Translation, Modification and Transport

Author(s): Ran Wei, Libin Guo, Qingshui Wang, Jin Miao, Hang Fai Kwok*, Yao Lin*.

Journal Name: Current Protein & Peptide Science

Volume 20 , Issue 1 , 2019

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Graphical Abstract:


Programmed death ligand 1 (PD-L1) is a cell membrane protein that binds to programmed cell death protein 1 (PD-1) on the effector T cells and transduces immunosuppressive signals. It is now clear that the expression of the PD-L1 protein on the tumor cell surface is critical for tumor cells to escape immunosuppression. At present, more attention is focused on the transcriptional regulation of PDL1 mRNA. However, PD-L1 protein is the functional unit involved in immunotherapy response. It is essential to deeply understand how this membrane protein is regulated post-transcriptionally in tumors and immune cells. In this review, we summarize the recent progress on the translation, modification and transport of PD-L1 protein.

Keywords: Programmed death ligand 1 (PD-L1), programmed cell death protein 1 (PD-1), immunotherapy, translation, modification, transport.

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Article Details

Year: 2019
Page: [82 - 91]
Pages: 10
DOI: 10.2174/1389203719666180928105632
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