Intracerebral hemorrhage (ICH), which accounts for 10% of all strokes, leads
to higher morbidity and mortality compared with other stroke subtypes. Hypertension has
been recognized as a major risk factor for ICH. Current antihypertensive options have
not been fully effective for either prevention of ICH or ameliorating its complications.
Therefore, attempts should be made to use novel antihypertensive medications for more
effective management of blood pressure (BP) in the acute phase of ICH. Imidazoline
receptor (IR) agonists can potentially be effective agents for BP control with the
adjunctive ability to attenuate post-ICH brain injury. IR agonists render neuroprotective
effects including inhibition of inflammatory reactions, apoptotic cell death, excitotoxicity,
and brain edema. Given these properties, the present review aims to focus on the
application of IR agonists for managing BP in ICH patients.
Keywords: Intracerebral haemorrhage, hypertension, imidazoline receptors, inflammation, excitotoxicity, apoptosis.
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