Sugars and Sweeteners: Structure, Properties and In Silico Modeling

(E-pub Ahead of Print)

Author(s): Dusanka Janezic, Lorentz Jantschi*, Sorana D. Bolboaca.

Journal Name: Current Medicinal Chemistry


Several studies report the effects of excessive use of sugars and sweeteners in the diet. These include obesity, cardiac diseases, diabetes, and even lymphomas, leukemias, cancers of the bladder and brain, chronic fatigue syndrome, Parkinson's disease, Alzheimer's disease, multiple sclerosis, autism, and systemic lupus. On the other hand, each sugar and sweetener has a distinct metabolic assimilation process, and its chemical structure plays an important role in this process. Several scientific papers present the biological effects of the sugars and sweeteners in relation to their chemical structure. One important issue dealing with the sugars is the degree of similarity in their structures, focusing mostly on optical isomerism. Finding and developing new sugars and sweeteners with desired properties is an emerging research area, in which in silico approaches play an important role.

Keywords: monosaccharides, disaccharides, glucose isomers, carbohydrates, diet, quantitative structure-taste relationships (QSTR).

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(E-pub Ahead of Print)
DOI: 10.2174/0929867325666180926144401
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