Alzheimer's Disease and Oxidative Stress
Pp. 172-201 (30)
Andrea R. Vasconcelos, Paula F. Kinoshita, Cristoforo Scavone and Elisa M. Kawamoto
Alzheimer's disease is a neurodegenerative disorder with no cure and not
completely understood mechanisms. This devastating disease is one of the main causes
of dementia in elderly people worldwide. Among different mechanisms of neuronal
death associated to Alzheimer's disease, oxidative stress can be considered as one of
the most studied. Several data from literature in this field have shown that oxidative
stress seems to be a critical step in the neurodegenerative course of the disease. Clinical
trials using antioxidants have described conflicting results, some of them supporting
the importance of the use of antioxidant compounds to ameliorate disease's symptoms
and the others showing negative results in terms of beneficial effects of antioxidant
therapy in the disease progression.
Alzeimer’s Disease, Antioxidants, Neurodegeneration, Oxidative
Pharmacology Department, Instituto de Ciencias Biomédicas, Universidade de Sao Paulo, Sao Paulo, Brazil.