Recent Advances in Alzheimer Research

Recent Advances in Alzheimer Research

Volume: 2

Cellular Mechanisms in Alzheimer`s Disease

Indexed in: Scopus, EBSCO.

Alzheimer’s Disease (AD) is the product of the slow and progressive degenerative alteration that develops in the adult brain and can remain asymptomatic for a considerable time before cognitive ...
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Alzheimer's Disease and Oxidative Stress

Pp. 172-201 (30)

Andrea R. Vasconcelos, Paula F. Kinoshita, Cristoforo Scavone and Elisa M. Kawamoto

Abstract

Alzheimer's disease is a neurodegenerative disorder with no cure and not completely understood mechanisms. This devastating disease is one of the main causes of dementia in elderly people worldwide. Among different mechanisms of neuronal death associated to Alzheimer's disease, oxidative stress can be considered as one of the most studied. Several data from literature in this field have shown that oxidative stress seems to be a critical step in the neurodegenerative course of the disease. Clinical trials using antioxidants have described conflicting results, some of them supporting the importance of the use of antioxidant compounds to ameliorate disease's symptoms and the others showing negative results in terms of beneficial effects of antioxidant therapy in the disease progression.

Keywords:

Alzeimer’s Disease, Antioxidants, Neurodegeneration, Oxidative stress.

Affiliation:

Pharmacology Department, Instituto de Ciencias Biomédicas, Universidade de Sao Paulo, Sao Paulo, Brazil.