Background: Heterocyclic compounds have received much attention due
to their versatile applications in the field of medicinal chemistry as well as organic
Objective: The main objective of this review is to give an overview of the recent application
of β-cyclodextrin catalyzed one–pot multicomponent reactions for the synthesis of
different assemblies of heterocycles.
Method: In this review, we have summarized the one-pot multicomponent approach towards
the synthesis of heterocyclic compounds by using β-cyclodextrin as a
supramolecular catalyst. It is outlined under the headings (1) five-membered heterocyclic
compounds and (2) six and seven membered heterocyclic compounds.
Conclusion: This review outlined the recent key developments in the synthesis of different O-, N- and S- containing
heterocyclic scaffolds, following MCRs published by using β-CD and its derivatives as a supramolecular
catalyst for the synthesis of five, six and seven membered heterocycles. The versatility of cyclodextrins and
modified cyclodextrins will encourage chemists to develop new heterocyclic molecules by using multicomponent
reactions in the near future.