Diabetes mellitus is a chronic metabolic health condition affecting the steady state of blood
sugar level. The usual method of administration is subcutaneous injection of insulin. There are several
ways to subcutaneously inject insulin, such as syringes, insulin pens, and insulin pumps. However,
subcutaneous injections of insulin can lead to discomfort, pain and local infection. This review focuses
on traditional methods of insulin administration, non-invasive approaches, and new insulin therapy
technologies, and the advantages and disadvantages of these approaches, as well as future development
prospects are also discussed.
Keywords: Drug delivery systems, diabetes mellitus, insulin delivery, oral insulin, insulin administration, review.
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