There is a need for the development of liposomes based nanomedicines formulation
for better efficacy and safety of the available drugs in the market. Liposomes have various
applications in the field of pharmaceutical and medical field for their drug target potential,
diagnostic importance and imaging techniques. Natural plant based drugs and their derivatives
have been used in the medicine, nutraceuticals, perfumery, cosmetic and beverages
industry. More than half of the prescribed drugs in the worldwide are mainly derived from
different natural sources. Development of plant derived product is an emerging field of food,
pharmaceutical and health industries. Plants belonging to the Gentianaecae family are well
known for their bitter taste and Swertia chirata is one of best plants among them. Various
active phytochemical of Swertia chirata are bitter secoiridoids like gentiopicroside,
amarogentin, swertiamarin, isovitexin and isogentisin. People use different species of Swertia
in the form of decoction, infusion, paste and juice for the treatment of fever and enteric diseases.
Swertia chirata possesses anticarcinogenic, antioxidative, hypoglycemic, antihepatotoxic,
antimalarial, anti-inflammatory and antimicrobial activities. Amarogentin, a bitter
secoiridoid glycoside present in Swertia chirata plant is an activator of human bitter taste
receptor. Pharmacologically, amarogentin has antibacterial, antihepatitis, anticholinergic and
chemopreventive activities, moreover, amarogentin has been proven for their anti-lieshmanial
activity. Other studies also suggested that amarogentin acts on liver carcinogenesis, skin carcinogenesis
and reduced tumour progression. In the present review, we have collected and
compiled the data regarding biological sources, ethnomedicinal uses, phytochemistry,
anticancer and anti-infective potential of amarogentin. For better understanding of various
aspects of amarogentin, we have also discussed Swertia chirayita in a very concise manner.
Further data related to various patents on amarogentin have also been discussed in this manuscript.
However, we also admit that new advance biological research will also increase the
medicinal and pharmacological value of amarogentin. Information regarding the chemistry of
amarogentin, its biological sources, bioavailability as a pharmacological agent for the treatment
and management of skin disorders and various forms of cancers will be beneficial to the
scientists in the medicinal field.