Ischemic Heart Disease (IHD) has been recognized as the main cause of mortality in the modern world.
Application of cell therapy technologies for the IHD treatment has been actively studied from the beginning of
2000s. The review is dedicated to the use of mesenchymal stem cells (MSC) in the therapy of IHD. The strategies
of the MSC modification in vitro for improvement of their regenerative potential are extensively discussed, including
preconditioning to enhance the cell survival, boosting their paracrine effect and manipulating their cardiomyogenic
differentiation. The optimization of the MSC delivery and opportunities related to the use of biomaterials
as cell carriers are also discussed. The results of the most important clinical studies on the MSC-based IHD
therapy are presented, including those completed and published in the literature and the ongoing clinical trials
registered at clinicaltrials.gov by June 2018.
Keywords: Ischemic heart disease, mesenchymal stem cells, cell therapy, regenerative medicine, clinical trials, MSC-based IHD.
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