The skin is one of the crucial body organs with anatomy and physiology linked to various
disorders including congenital and acquired diseases. Nowadays, mesenchymal stem cell (MSCs)-
based therapy has appeared as a promising therapeutic field, in which many see opportunities to cure
the costliest and incurable diseases. However, one question to be asked is that if the use of MSCs in
clinical trials studies and diseases treatment has improved. In this study, the clinical trials using MSCs
in skin diseases were reviewed. A remarkable number of clinical trial studies are in progress in this
field; however, only a few of them have led to tangible benefits for patients. The relevant papers and
ongoing clinical trials that address MSC’s therapeutic goals for various skin disorders were examined.
This review can be very useful for both the dermatologists and basic skin researchers interested in contributing
to stem cell-based therapeutic researches in the area of skin disorders.
Keywords: Cell therapy, clinical trial, mesenchymal stem cells, skin diseases, cell-based, dermatologists.
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