Shaping and Cellular Uptake of Folic Acid Coated Gold and Magnetite Nanoparticles

Author(s): Ahmed A.G. El-Shahawy*, Gamal Elghnam, Alsayed A.M. Alsherbini.

Journal Name: Current Nanomedicine
Formerly Recent Patents on Nanomedicine

Volume 9 , Issue 2 , 2019

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Abstract:

Background: Gold and Iron Oxide nanoparticles NPs play as nanocarriers for a specific drug delivery and contrast agents. Intercellular uptake of these nanoparticles and targeting to individual cell and sub-cellular compartment is essential.

Objective: The aim of the current study is to evaluate the intracellular uptake of these NPs to specific tumor cells in vitro conjugated with folic acid with a goal of enhancing the efficiency of specific targeting to tumor cells.

Methods: We synthesized the nanoparticles by a chemical method and characterized by UV-Visible, FTIR, XRD, and TEM.

Results & Conclusion: The results revealed the conjugation of Gold and Iron Oxide nanoparticles with folic acid increased the intercellular uptake with high percent compared to non- conjugated nanoparticles.

Keywords: Gold, Iron oxide nanoparticles, folate receptors, intracellular uptake, folic acid, magnetite nanoparticles.

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2019
Page: [166 - 172]
Pages: 7
DOI: 10.2174/2468187308666180913113827
Price: $58

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