Background: Non-Steroidal Anti Inflammation Drugs (NSAIDs) have shown effectivity
in pain relief and are the most prescribed around the world. However, NSAIDs impair hematological
aspects that may lead to the life-threatening events.
Objective: The objective of the study is to determine the comparison and impact of the short-term use
of some non-aspirin NSAIDs on bleeding time.
Method: We have 10 animals group. Each group contains 4 animals. Normal group, ketoprofen (0.26
mg/ 20 g BW of mice twice daily), ketorolac (0.078 mg/ 20 g BW of mice twice daily), diclofenac
(0.13 mg/ 20 g BW of mice twice daily), piroxicam (0.052 mg/ 20 g BW of mice once daily),
mefenamic acid (1.3 mg/ 20 g BW of mice thrice daily), meloxicam (0.039 mg/ 20 g BW of mice
once daily), celecoxib (0.52 mg/ 20 g BW of mice once daily), ibuprofen (1.04 mg/ 20 g BW of mice
thrice daily) and paracetamol group (1.3 mg/ 20 g BW of mice thrice daily). The treatment length
is 5 days. Bleeding time determination was conducted one hour after the last treatment.
Results: All test group showed an elevation of the bleeding time by 59.78%, 156.50%, 108.73%,
99.96%, 22.59%, 85.46%, 69.66%, 42.24%, and 45.08% for meloxicam, ketoprofen, ketorolac,
diclofenac sodium, paracetamol, piroxicam, mefenamic acid, ibuprofen and celecoxib than normal
groups, respectively. Ketoprofen gives the highest bleeding time elevation.
Conclusion: Ketoprofen gives the highest bleeding time elevation while paracetamol gives the
lowest bleeding time elevation.