Phosphazene Base-Catalyzed Double Michael Addition: Stereoselective Synthesis of Cyclohexanones

Author(s): Yang-Guo Li, Yang Zhang, Guang-Fen Du*, Cheng-Zhi Gu, Lin He*.

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 1 , 2019

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Abstract:

Phosphazene bases have been utilized as efficient organocatalysts to catalyze the double Michael additions of divinyl ketones with active methylenes to afford functionalized cyclohexanones in 36-91% yields with >25:1 diastereoselectivity.

Keywords: Phosphazene base, double Michael addition, cyclohexanone, organocatalysis, divinyl ketone, methylene.

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Article Details

VOLUME: 16
ISSUE: 1
Year: 2019
Page: [76 - 80]
Pages: 5
DOI: 10.2174/1570178615666180912115748
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