LGE-MRI in the Assessment of Left-ventricular Remodelling in Myocarditis

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Author(s): Wei-Feng Yuan, Xin-Xiang Zhao*, Wen-Jing Sun, Shao-Ping Wu, Ya-Bin Liu, Xi Tang.

Journal Name: Current Medical Imaging

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Purpose: The exact morbidity of myocarditis is unknown, as the treatment is generally delayed in virtue of misdiagnosis or missed diagnosis. The aim of this study was to identify prognostic factors of left-ventricular remodeling on CMRI performed in patients with pathological proven myocarditis.

Materials and Methods: Sixty-two cases with various presentations of myocarditis (39 cases with heart failure; 23 cases with arrhythmias) were selected. All patients, who underwent coronary angiography, endomyocardial biopsy, were divided into positive-remodeling and negativeremodelling groups to analyse LGE and cardiac cine parameters at presentation and subsequent to 3 months.

Result: Comparison of two subgroups in CMRI is as follows: positive LGE (65.6% vs. 86.7%; p<0.05), LVEF (41.3±14.8% vs. 37.6±10.1%; p=0.62), (25.7±2.0% vs. 24.0±2.5%; p=0.81), (44.5±3.9mm vs. 46.3±5.4mm; p=0.76), (129.1±8.5ml vs. 135.3±12.2ml; p=0.26), (74.8±7.3ml vs. 79.1±10.0ml; p=0.55), (52.0±5.7g vs. 49.6±6.5g; p=0.71), (34.9±3.5ml vs. 32.4±6.2ml; p=0.68), (3.8±0.7L/min vs. 3.1±0.5L/min; p=0.64), (2.9±0.6L/min*m2 vs. 2.7±0.5L/min*m2; p=0.79).

Conclusion: LGE-MRI is rewarding as an independent predictor in left-ventricular positive and negative remodelling of myocarditis.

Keywords: Myocarditis, remodelling, heart failure, arrhythmias, magnetic resonance imaging

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(E-pub Ahead of Print)
DOI: 10.2174/1573405614666180912100253

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