Abstract
In nature, microbes do not exist in isolation but co-exist in a variety of ecological and biological environments and on various host organisms. Due to their close proximity, these microbes interact among themselves, and also with the hosts in both positive and negative manners. Moreover, these interactions may modulate dynamically upon external stimulus as well as internal community changes. This demands systematic techniques such as mathematical modeling to understand the intrinsic community behavior. Here, we reviewed various approaches for metabolic modeling of microbial communities. If detailed species-specific information is available, segregated models of individual organisms can be constructed and connected via metabolite exchanges; otherwise, the community may be represented as a lumped network of metabolic reactions. The constructed models can then be simulated to help fill knowledge gaps, and generate testable hypotheses for designing new experiments. More importantly, such community models have been developed to study microbial interactions in various niches such as host microbiome, biogeochemical and bioremediation, waste water treatment and synthetic consortia. As such, the metabolic modeling efforts have allowed us to gain new insights into the natural and synthetic microbial communities, and design interventions to achieve specific goals. Finally, potential directions for future development in metabolic modeling of microbial communities were also discussed.
Keywords: Microbial communities, Metabolism, Community modeling, Genome-scale metabolic models, Flux balance analysis, Kinetic models.
Current Genomics
Title:Metabolic Modeling of Microbial Community Interactions for Health, Environmental and Biotechnological Applications
Volume: 19 Issue: 8
Author(s): Kok Siong Ang, Meiyappan Lakshmanan, Na-Rae Lee and Dong-Yup Lee*
Affiliation:
- Bioprocessing Technology Institute (BTI), A*STAR, Singapore 138668,Singapore
Keywords: Microbial communities, Metabolism, Community modeling, Genome-scale metabolic models, Flux balance analysis, Kinetic models.
Abstract: In nature, microbes do not exist in isolation but co-exist in a variety of ecological and biological environments and on various host organisms. Due to their close proximity, these microbes interact among themselves, and also with the hosts in both positive and negative manners. Moreover, these interactions may modulate dynamically upon external stimulus as well as internal community changes. This demands systematic techniques such as mathematical modeling to understand the intrinsic community behavior. Here, we reviewed various approaches for metabolic modeling of microbial communities. If detailed species-specific information is available, segregated models of individual organisms can be constructed and connected via metabolite exchanges; otherwise, the community may be represented as a lumped network of metabolic reactions. The constructed models can then be simulated to help fill knowledge gaps, and generate testable hypotheses for designing new experiments. More importantly, such community models have been developed to study microbial interactions in various niches such as host microbiome, biogeochemical and bioremediation, waste water treatment and synthetic consortia. As such, the metabolic modeling efforts have allowed us to gain new insights into the natural and synthetic microbial communities, and design interventions to achieve specific goals. Finally, potential directions for future development in metabolic modeling of microbial communities were also discussed.
Export Options
About this article
Cite this article as:
Ang Siong Kok , Lakshmanan Meiyappan , Lee Na-Rae and Lee Dong-Yup *, Metabolic Modeling of Microbial Community Interactions for Health, Environmental and Biotechnological Applications, Current Genomics 2018; 19 (8) . https://dx.doi.org/10.2174/1389202919666180911144055
DOI https://dx.doi.org/10.2174/1389202919666180911144055 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Electroencephalographic Profiles of Children with Symptoms of Attention Deficit Hyperactivity Disorder: A Review of the Literature
Current Pediatric Reviews Ethnicity Considerations in Diagnosing Glucose Disorders
Current Diabetes Reviews Roles of L5-7 Loop in the Structure and Chaperone Function of SsHSP14.1
Protein & Peptide Letters Hypertension in Obstructive Sleep Apnoea
Vascular Disease Prevention (Discontinued) RNAi Screening Identifies TAK1 as a Potential Target for the Enhanced Efficacy of Topoisomerase Inhibitors
Current Cancer Drug Targets One-pot Synthesis and its Practical Application in Pharmaceutical Industry
Current Organic Synthesis Streptozotocin-Induced Diabetes Mellitus in Neonatal Rats: An Insight into its Applications to Induce Diabetic Complications
Current Diabetes Reviews A General Approach on Surfactants Use and Properties in Drug Delivery Systems
Current Pharmaceutical Design Trends in Annatto Agroindustry: Bixin Processing Technologies and Market
Recent Patents on Engineering Myofascial Temporomandibular Disorder
Current Rheumatology Reviews Biomarkers in Asthma and COPD
Recent Patents on Biomarkers Editorial [Hot topic: New Developments in the Treatment and Prevention of Vascular Disease - Part 1 (Executive Editors: N. Katsiki, V.G. Athyros and D.P. Mikhailidis)]
Current Pharmaceutical Design Effect of Fetal and Neonatal Hypothyroidism on Glucose Tolerance in Middle- Aged Female Rats
Endocrine, Metabolic & Immune Disorders - Drug Targets Pharmacologic Therapy for Cardiovascular Risk Reduction in Patients with the Metabolic Syndrome
Current Pharmaceutical Design Novel Vaginal Drug Delivery Systems: A Review
Current Drug Therapy Mechanisms of Esophageal Protection, Gastroprotection and Ulcer Healing by Melatonin. Implications for the Therapeutic use of Melatonin in Gastroesophageal Reflux Disease (GERD) and Peptic Ulcer Disease
Current Pharmaceutical Design Mutations of the Apolipoprotein A5 Gene with Inherited Hypertriglyceridaemia: Review of the Current Literature
Current Medicinal Chemistry Applications of Important Polysaccharides in Drug Delivery
Current Pharmaceutical Design Phosphodiesterase Type 5 Inhibitors for the Management of Erectile Dysfunction: Preference and Adherence to Treatment
Current Pharmaceutical Design ACKNOWLEDGEMENTS TO REVIEWERS
Current Diabetes Reviews