The FOXO (Forkhead box O) transcription factors are implicated in several signaling pathways and
play a vital role in various cellular and physiological processes include for instance, ROS (reactive oxygen species)
response, cell proliferation, regulation of programmed cell death, longevity, metabolism and cancer and
regulation of cell cycle. In humans, the four FOXO family members are responsible for resemblance in their
structure, regulation and functions. FOXO1 gene is highly expressed in adipose tissues and it affects the regulation
of glycogenolysis and gluconeogenesis through insulin signaling. The gene of FOXO3 is highly expressed in
the kidney, heart, spleen and brain and is characterized as diverse forkhead DNA-binding domain of transcription
factors. The FOXO3 is a tumor suppressor gene and found to interact with p53, the trigger for apoptosis through
BCl2 family genes and a regulator of Notch signaling pathway for the self-renewal of stem cells. Therefore,
FOXOs remains to be a fascinating and potential target to acquire novel therapeutic approaches to cure cancer.
This review will provide a comprehensive overview about the biology of FOXO proteins, which can be utilized
for developing current therapeutic approaches to treat cancer.
Keywords: Forkhead box O, therapeutic, cancer, polymorphism, transcription factors, cell proliferation.
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